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Full-Text Articles in Physical Sciences and Mathematics
Associations Of Hemodynamics, Morphology, And Patient Characteristics With Aneurysm Rupture Stratified By Aneurysm Location, Felicitas J. Detmer, Bong Jae Chung, Carlos Jimenez, Farid Hamzei-Sichani, David Kallmes, Christopher Putman, Juan R. Cebral
Associations Of Hemodynamics, Morphology, And Patient Characteristics With Aneurysm Rupture Stratified By Aneurysm Location, Felicitas J. Detmer, Bong Jae Chung, Carlos Jimenez, Farid Hamzei-Sichani, David Kallmes, Christopher Putman, Juan R. Cebral
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
Purpose: The mechanisms of cerebral aneurysm rupture are not fully understood. We analyzed the associations of hemodynamics, morphology, and patient age and gender with aneurysm rupture stratifying by location. Methods: Using image-based models, 20 hemodynamic and 17 morphological parameters were compared in 1931 ruptured and unruptured aneurysms with univariate logistic regression. Rupture rates were compared between males and females as well as younger and older patients and bifurcation versus sidewall aneurysms for different aneurysm locations. Subsequently, associations between hemodynamics and morphology and patient as well as aneurysm characteristics were analyzed for aneurysms at five locations. Results: Compared to unruptured aneurysms, …
Hemodynamic Characteristics Of Stable And Unstable Vertebrobasilar Dolichoectatic And Fusiform Aneurysms, Waleed Brinjikji, Bong Jae Chung, Ding Yong-Hong, John T. Wald, Fernando Mut, Ramanathan Kadirvel, David F. Kallmes, Aymeric Rouchaud, Giuseppe Lanzino, Juan R. Cebral
Hemodynamic Characteristics Of Stable And Unstable Vertebrobasilar Dolichoectatic And Fusiform Aneurysms, Waleed Brinjikji, Bong Jae Chung, Ding Yong-Hong, John T. Wald, Fernando Mut, Ramanathan Kadirvel, David F. Kallmes, Aymeric Rouchaud, Giuseppe Lanzino, Juan R. Cebral
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
Background and purpose Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. Materials and methods VBDAs with CT angiography or MR angiography followed longitudinally without treatment were studied. Unstable aneurysms were defined as those that grew or ruptured during follow-up. Aneurysms associated with stroke were defined as those associated with posterior circulation infarct at follow-up. Baseline data, including demographics, comorbidities, and aneurysm morphology and size were collected. …
Hemodynamic Differences Between Unstable And Stable Unruptured Aneurysms Independent Of Size And Location: A Pilot Study, Waleed Brinjikji, Bong Jae Chung, Carlos Jimenez, Christopher Putman, David F. Kallmes, Juan R. Cebral
Hemodynamic Differences Between Unstable And Stable Unruptured Aneurysms Independent Of Size And Location: A Pilot Study, Waleed Brinjikji, Bong Jae Chung, Carlos Jimenez, Christopher Putman, David F. Kallmes, Juan R. Cebral
Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works
Background While clinical and angiographic risk factors for intracranial aneurysm instability are well established, it is reasonable to postulate that intra-aneurysmal hemodynamics also have a role in aneurysm instability. Objective To identify hemodynamic characteristics that differ between radiologically unstable and stable unruptured intracranial aneurysms. Materials and methods 12 pairs of unruptured intracranial aneurysms with a 3D rotational angiographic set of images and followed up longitudinally without treatment were studied. Each pair consisted of one stable aneurysm (no change on serial imaging) and one unstable aneurysm (demonstrated growth of at least 1 mm diameter or ruptured during follow-up) of matching size …