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Area under the ROC curve; Biomarker; Diagnostic medicine; Prediction accuracy; Receiver Operating Characteristic; Survival prediction
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Full-Text Articles in Physical Sciences and Mathematics
A Simple Method To Estimate The Time-Dependent Roc Curve Under Right Censoring, Liang Li, Bo Hu, Tom Greene
A Simple Method To Estimate The Time-Dependent Roc Curve Under Right Censoring, Liang Li, Bo Hu, Tom Greene
Liang Li
The time-dependent Receiver Operating Characteristic (ROC) curve is often used to study the diagnostic accuracy of a single continuous biomarker, measured at baseline, on the onset of a disease condition when the disease onset may occur at different times during the follow-up and hence may be right censored. Due to censoring, the true disease onset status prior to the pre-specified time horizon may be unknown on some patients, which causes difficulty in calculating the time-dependent sensitivity and specificity. We study a simple method that adjusts for censoring by weighting the censored data by the conditional probability of disease onset prior …