Physical Sciences and Mathematics Commons^™

Measures For The Degree Of Overlap Of Gene Signatures And Applications To Tcga, Shuangge Ma

Shuangge Ma

For cancer and many other complex diseases, a large number of gene signatures have been generated. In this study, we use cancer as an example and note that other diseases can be analyzed in a similar manner. For signatures generated in multiple studies on the same cancer type/outcome, and for signatures on different cancer types, it is of interest to evaluate their degree of overlap. Many of the existing studies simply count the number (or percentage) of overlapped genes shared by two signatures. Such an approach has serious limitations. In this study, as a demonstrating example, we consider cancer prognosis …