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Full-Text Articles in Physical Sciences and Mathematics
An Analysis Of All-Cause Mortality On Patients With Sickle Cell Disease And Kidney Disease Using Propensity Score Matching, Adam Garrison
An Analysis Of All-Cause Mortality On Patients With Sickle Cell Disease And Kidney Disease Using Propensity Score Matching, Adam Garrison
Electronic Theses and Dissertations
In this work, we provide an overview of the Cox proportional hazards model for time to event or survival analysis and the notion of propensity score matching to deal with confounding factors. A full analysis is reported in Chapter 2 concerning mortality for in-center dialysis patients with sickle cell disease to demonstrate the application of a general analysis strategy that has some logistical benefits over more traditional approaches to accounting for confounding variables. We also provide some insight and discussions on the challenges and future research questions that will emerge when trying to implement this strategy as a monitoring tool …
Variable Selection In Accelerated Failure Time (Aft) Frailty Models: An Application Of Penalized Quasi-Likelihood, Sarbesh R. Pandeya
Variable Selection In Accelerated Failure Time (Aft) Frailty Models: An Application Of Penalized Quasi-Likelihood, Sarbesh R. Pandeya
Electronic Theses and Dissertations
Variable selection is one of the standard ways of selecting models in large scale datasets. It has applications in many fields of research study, especially in large multi-center clinical trials. One of the prominent methods in variable selection is the penalized likelihood, which is both consistent and efficient. However, the penalized selection is significantly challenging under the influence of random (frailty) covariates. It is even more complicated when there is involvement of censoring as it may not have a closed-form solution for the marginal log-likelihood. Therefore, we applied the penalized quasi-likelihood (PQL) approach that approximates the solution for such a …