Physical Sciences and Mathematics Commons^™

Sers Platform For Single Fiber Endoscopic Probes, Debsmita Biswas

LSU Doctoral Dissertations

Molecular detection techniques have huge potential in clinical environments. In addition to many other molecular detection techniques, endoscopic Raman spectroscopy has great ability in terms of minimal invasiveness and real-time spectra acquisition. However, Raman Effect is low in sensitivity, limiting the application. Surface-Enhanced Raman Scattering (SERS), addresses this limitation. SERS brings rough nano-metallic surfaces in contact with specimen molecules which enormously enhances Raman signals. This provides Raman spectroscopy with immense capabilities for diverse fields of applications.

Generally, in clinical probe applications, the spectrometer is brought near the target molecules for detection. Typically, optical fibers are used to couple spectrometers to …

Optimizing The Plasmonic Enhancement Of Light In Metallic Nanogap Structures For Surface-Enhanced Raman Spectroscopy, Stephen Joseph Bauman

Graduate Theses and Dissertations

Technology based on the interaction between light and matter has entered something of a renaissance over the past few decades due to improved control over the creation of nanoscale patterns. Tunable nanofabrication has benefitted optical sensing, by which light is used to detect the presence or quantity of various substances. Through methods such as Raman spectroscopy, the optical spectra of solid, liquid, or gaseous samples act as fingerprints which help identify a single type of molecule amongst a background of potentially many other chemicals. This technique therefore offers great benefit to applications such as biomedical sensors, airport security, industrial waste …

Investigating The Potential Applications Of A Raman Tweezer System, John Wray

Theses and Dissertations

This thesis describes the construction of an Optical Tweezer apparatus to be used in conjunction with a confocal Raman spectrometer. The tweezer utilizes an infrared (λ=1064 nm) laser directed into an inverted microscope with NA=1.4 oil immersion 100x objective lens that strongly focuses the laser light into a sample to function as a single-beam gradient force trap. The long term goal of this research program is to develop a single molecule Raman tweezers apparatus that allows one to control the position of a Raman nanoplasmonic amplifier. This thesis describes the construction of the Raman tweezer apparatus along with several Raman …