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Articles 1 - 9 of 9
Full-Text Articles in Physical Sciences and Mathematics
Advanced Raman Spectroscopy Detection Of Oxidative Damage In Nucleic Acid Bases: Probing Chemical Changes And Intermolecular Interactions In Guanosine At Ultralow Concentration, Francesca Ripanti, Claudia Fasolato, Flavia Mazzarda, Simonetta Palleschi, Marina Ceccarini, Chunchun Li, Margherita Bignami, Enrico Bodo, Steven E.J. Bell, Filomena Mazzei, Paolo Postorino
Advanced Raman Spectroscopy Detection Of Oxidative Damage In Nucleic Acid Bases: Probing Chemical Changes And Intermolecular Interactions In Guanosine At Ultralow Concentration, Francesca Ripanti, Claudia Fasolato, Flavia Mazzarda, Simonetta Palleschi, Marina Ceccarini, Chunchun Li, Margherita Bignami, Enrico Bodo, Steven E.J. Bell, Filomena Mazzei, Paolo Postorino
Bioelectrics Publications
DNA/RNA synthesis precursors are especially vulnerable to damage induced by reactive oxygen species occurring following oxidative stress. Guanosine triphosphates are the prevalent oxidized nucleotides, which can be misincorporated during replication, leading to mutations and cell death. Here, we present a novel method based on micro-Raman spectroscopy, combined with ab initio calculations, for the identification, detection, and quantification of oxidized nucleotides at low concentration. We also show that the Raman signature in the terahertz spectral range (<100 >cm(-1)) contains information on the intermolecular assembly of guanine in tetrads, which allows us to further boost the oxidative damage detection limit. Eventually, we …
Electron Tunneling And X-Ray Photoelectron Spectoscopy Studies Of The Superconductiong Properties Of Nitrogen-Doped Niobium Resonator Cavities, Eric M. Lechner, Basu Dev Oli, Junki Makita, Gianluigi Ciovati, Alex Gurevich, Maria Iavarone
Electron Tunneling And X-Ray Photoelectron Spectoscopy Studies Of The Superconductiong Properties Of Nitrogen-Doped Niobium Resonator Cavities, Eric M. Lechner, Basu Dev Oli, Junki Makita, Gianluigi Ciovati, Alex Gurevich, Maria Iavarone
Physics Faculty Publications
We use scanning tunneling microscopy (STM) and spectroscopy (STS), and x-ray photoelectron spectroscopy (XPS) to investigate the effect of nitrogen doping on the surface electronic and chemical structures of cutouts from superconducting Nb radio-frequency cavities. The goal of this work is to get insights into the fundamental physics and materials mechanisms behind the striking decrease of the surface resistance with the radio-frequency magnetic field, which has been observed on N-doped Nb cavities. Our XPS measurements reveal significantly more oxidized Nb 3d states and a thinner metallic suboxide layer on the N-doped Nb surfaces, which is also confirmed by tunneling spectroscopy …
Thermal Oxidation Of Silicon In A Home-Made Furnace System, Joshua Koskan
Thermal Oxidation Of Silicon In A Home-Made Furnace System, Joshua Koskan
Physics Capstone Projects
I approached Dr. Shen with a desire for a project in understanding how to manage and expand the capabilities of a laboratory. After some discussion, my senior project was to complete a gas and water chiller system to an existing furnace for chemical vapor deposition. It should be able to handle temperatures up to 1100 ºC, hold a vacuum to mTorr, be easy to move samples in and out of the furnace, and cost effective.
No2- And No3- Enhance Cold Atmospheric Plasma Induced Cancer Cell Death By Generation Of Onoo-, Dehui Xu, Qingjie Cui, Yujing Xu, Zhijie Liu, Zeyu Chen, Wenjie Xia, Hao Zhang, Dingxin Liu, Hailan Chen, Michael G. Kong
No2- And No3- Enhance Cold Atmospheric Plasma Induced Cancer Cell Death By Generation Of Onoo-, Dehui Xu, Qingjie Cui, Yujing Xu, Zhijie Liu, Zeyu Chen, Wenjie Xia, Hao Zhang, Dingxin Liu, Hailan Chen, Michael G. Kong
Bioelectrics Publications
Cold atmospheric plasma (CAP) is a rapidly developed technology that has been widely applied in biomedicine especially in cancer treatment. Due to the generation of various active species in plasma, CAP could induce various tumor cells death and showed a promising potential in cancer therapy. To enhance the biological effects of gas plasma, changing the discharging parameters is the most commonly used method, yet increasing discharging power will lead to a higher possibility of simultaneously damage surrounding tissues. In this study, by adding nontoxic concentration of additional nitrite and nitrate in the medium, we found that anti-tumor effect of CAP …
Interaction Between Air Plasma-Produced Aqueous 1o2 And The Spin Trap Dmpo In Electron Spin Resonance, Chen Chen, Fanying Li, Hai-Lan Chen, Michael G. Kong
Interaction Between Air Plasma-Produced Aqueous 1o2 And The Spin Trap Dmpo In Electron Spin Resonance, Chen Chen, Fanying Li, Hai-Lan Chen, Michael G. Kong
Bioelectrics Publications
A series of electron spin resonance (ESR) experiments is done to quantitatively measure the concentrations of aqueous 1O2 and OH produced by a surface micro-discharge air plasma device. 1O2 is tested to be existed in the plasma treated solution by using the spin trap of TEMP. However, the unexpected DMPOX spectrum is observed in measuringOH by the spin trap of 5,5-Dimethyl-1-Pyrroline-N-Oxide (DMPO). With more chemical scavenger experiments, it is found that removal of aqueous 1O2 leads to the disappearance of DMPOX in ESR. Therefore, the generation of DMPOX is directly related to the oxidation …
Low Temperature Photo-Oxidation Of Chloroperoxidase Compound Ii, Xinting Yuan, Xin Sheng, John A. Horner, Brian Bennett, Leslie W. -M. Fung, Martin Newcomb
Low Temperature Photo-Oxidation Of Chloroperoxidase Compound Ii, Xinting Yuan, Xin Sheng, John A. Horner, Brian Bennett, Leslie W. -M. Fung, Martin Newcomb
Physics Faculty Research and Publications
Oxidation of the heme-thiolate enzyme chloroperoxidase (CPO) from Caldariomyces fumago with peroxynitrite (PN) gave the Compound II intermediate, which was photo-oxidized with 365 nm light to give a reactive oxidizing species. Cryo-solvents at pH ≈ 6 were employed, and reactions were conducted at temperatures as low as − 50 °C. The activity of CPO as evaluated by the chlorodimedone assay was unaltered by treatment with PN or by production of the oxidizing transient and subsequent reaction with styrene. EPR spectra at 77 K gave the amount of ferric protein at each stage in the reaction sequence. The PN oxidation step …
Compositional Stability Of Fept Nanoparticles On Sio2/Si During Annealing, Richard R. Vanfleet, B. Yao, R. V. Petrova, K. R. Coffey
Compositional Stability Of Fept Nanoparticles On Sio2/Si During Annealing, Richard R. Vanfleet, B. Yao, R. V. Petrova, K. R. Coffey
Faculty Publications
The loss of Fe due to oxidation or diffusion into the substrate can prevent the successful preparation of well-ordered, stoichiometric, FePt nanoparticles. In this work we report the composition changes during annealing observed for small (<10 nm) FePt nanoparticles on thermally grown SiO2 layers on Si wafer substrates. Additionally, we describe the use of a controlled reducing gas mixture, Ar+H2+H2O, to reduce the loss of Fe.
Wet Chemical Digital Etching Of Gaas At Room Temperature, Gregory C. Desalvo, Christopher A. Bozada, John L. Ebel, David C. Look, John P. Barrette, Charles L. A. Cerny, Ross W. Dettmer, James K. Gillespie, Charles K. Havasy, Thomas J. Jenkins, Kenichi Nakano, Carl I. Pettiford, Tony K. Quach, James S. Sewell, G. David Via
Wet Chemical Digital Etching Of Gaas At Room Temperature, Gregory C. Desalvo, Christopher A. Bozada, John L. Ebel, David C. Look, John P. Barrette, Charles L. A. Cerny, Ross W. Dettmer, James K. Gillespie, Charles K. Havasy, Thomas J. Jenkins, Kenichi Nakano, Carl I. Pettiford, Tony K. Quach, James S. Sewell, G. David Via
Physics Faculty Publications
A new room temperature wet chemical digital etching technique for GaAs is presented which uses hydrogen peroxide and an acid in a two‐step etching process to remove GaAs in approximately 15 Å increments. In the first step, GaAs is oxidized by 30% hydrogen peroxide to form an oxide layer that is diffusion limited to a thickness of 14 to 17 Å for time periods from 15 to 120 s. The second step removes this oxide layer with an acid that does not attack unoxidized GaAs. These steps are repeated in succession until the desired etch depth is obtained. Experimental results …
Visible Luminescence From Single Crystal‐Silicon Quantum Wells, Peter N. Saeta, A. C. Gallagher
Visible Luminescence From Single Crystal‐Silicon Quantum Wells, Peter N. Saeta, A. C. Gallagher
All HMC Faculty Publications and Research
Single crystal‐silicon quantum wells with SiO2 barriers have been grown from SIMOX silicon‐on‐insulator substrates. Photoluminescence in the red and near‐infrared is observed for average well width <8 >nm, with peak signal for 2‐nm average width. The luminescence spectrum is independent of well width for SiO2 barriers, but shifts 0.3 eV to higher energy upon removal of the upper oxide layer with HF. Both results suggest the importance of radiation from surface states.