Physical Sciences and Mathematics Commons^™

Pregnancy And Fertility Amongst Women With The Mthfr C677t Polymorphism: An Anthropological Review, Caroline A. Maclean

USF Tampa Graduate Theses and Dissertations

Effects of the MTHFR C677T allele on reproduction include multiple complications. The frequency of births with neural tube defects, Down Syndrome, or recurrent pregnancy loss of CC, CT, and TT mothers was measured using data collected from existing literature. Total participants n=2605 (n=1111 cases, n=1494 controls). Results show that folic acid supplementation did not prevent the incidence of NTD pregnancy in CT women. Furthermore, CT women are more fecund overall, producing more pregnancies than CC and TT women. While CT case women did have higher incidences of RPL, NTD pregnancy and DS pregnancy, this is due to the overall greater …