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Full-Text Articles in Physical Sciences and Mathematics
Applications Of Amorphous Track Models In Radiation Biology, Francis Cucinotta, Hooshang Nikjoo, Dudley A. Goodhead
Applications Of Amorphous Track Models In Radiation Biology, Francis Cucinotta, Hooshang Nikjoo, Dudley A. Goodhead
Robert Katz Publications
The average or amorphous track model uses the response of a system to gamma-rays and the radial distribution of dose about an ion’s path to describe survival and other cellular endpoints from proton, heavy ion, and neutron irradiation. This model has been used for over 30 years to successfully fit many radiobiology data sets. We review several extensions of this approach that address objections to the original model, and consider applications of interest in radiobiology and space radiation risk assessment. In the light of present views of important cellular targets, the role of target size as manifested through the relative …
Tracks To Therapy, Robert Katz, F. A. Cucinotta
Tracks To Therapy, Robert Katz, F. A. Cucinotta
Robert Katz Publications
Studies of the structure of particle tracks have led to models of track effects based on radial dose and radiobiological target theory that have been very successful in describing and predicting track effects in physical, chemical, and biological systems. For describing mammalian cellular inactivation two inactivation modes are required, called gamma-kill aid ion-kill, the first due to synergistic effects of delta rays from adjacent ion paths thus resembling the effects from gamma rays, and the second to the effects of single ion transits through a cell nucleus. The ion-kill effect is more severe, where the fraction of cells experiencing ion …