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Full-Text Articles in Physical Sciences and Mathematics
Proof-Of-Concept For Converging Beam Small Animal Irradiator, Benjamin Insley
Proof-Of-Concept For Converging Beam Small Animal Irradiator, Benjamin Insley
Dissertations & Theses (Open Access)
The Monte Carlo particle simulator TOPAS, the multiphysics solver COMSOL., and
several analytical radiation transport methods were employed to perform an in-depth proof-ofconcept
for a high dose rate, high precision converging beam small animal irradiation platform.
In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for
high output and high directionality was designed and characterized. In the second aim, an
optimization algorithm was developed to customize a collimator geometry for this unique Xray
source to simultaneously maximize the irradiator’s intensity and precision. Then, a full
converging beam irradiator apparatus was fit with a multitude …
Novel Simulation To Avoid Bias In Measurement Of Hyperpolarized Pyruvate: Demonstrated In Phantom And In Vivo, Christopher M. Walker
Novel Simulation To Avoid Bias In Measurement Of Hyperpolarized Pyruvate: Demonstrated In Phantom And In Vivo, Christopher M. Walker
Dissertations & Theses (Open Access)
Dynamic nuclear polarization creates a transient hyperpolarized nuclear state that can dramatically increase the signal detected by magnetic resonance imaging. This signal increase allows real-time spectroscopic imaging of specific metabolites in vivo by magnetic resonance. Real-time imaging of both the spatial and chemical fate of hyperpolarized metabolites is showing great promise to meaningfully benefit clinical care of cancer patients. Imaging of hyperpolarized agents will have a larger clinical impact if it can function as a quantitative modality upon which clinical decisions can be made. However, quantitative measurement of hyperpolarized agents is currently difficult due to the restrictions imposed by the …