Physical Sciences and Mathematics Commons^™

Numerical Simulation Of Adaptive Metabolic Response To Anti-Angiogenic Treatment In Renal Cell Carcinoma, Saranya Varakunan

Undergraduate Student Research Internships Conference

Renal cell carcinoma, a malignant kidney cancer, is often treated using anti-angiogenic drugs to prevent the growth of blood vessels within the tumour. Although tumours initially respond to this treatment, they eventually develop resistance. This resistance is hypothesized to be caused by a switch to a symbiotic metabolism that allows cells to survive even with a low blood supply.

This project seeks to computationally model the transport of oxygen, lactate, and glucose within a tumour in order to examine how cancer metabolism adapts to changes in blood vessels.

Physically Based Rendering Techniques To Visualize Thin-Film Smoothed Particle Hydrodynamics Fluid Simulations, Aditya H. Prasad

Dartmouth College Undergraduate Theses

This thesis introduces a methodology and workflow I developed to visualize smoothed hydrodynamic particle based simulations for the research paper ’Thin-Film Smoothed Particle Hydrodynamics Fluid’ (2021), that I co-authored. I introduce a physically based rendering model which allows point cloud simulation data representing thin film fluids and bubbles to be rendered in a photorealistic manner. This includes simulating the optic phenomenon of thin-film interference and rendering the resulting iridescent patterns. The key to the model lies in the implementation of a physically based surface shader that accounts for the interference of infinitely many internally reflected rays in its bidirectional surface …

Statistical And Variational Modeling And Analysis Of Passive Integrated Photonic Devices, Norbert Dinyi Agbodo

Legacy Theses & Dissertations (2009 - 2024)

The success of Si as a platform for photonic devices and the associated availabilityof wafer-scale, ultra-high resolution lithography for Si CMOS has helped lead to the rapid advance of Si-based integrated photonics manufacturing over the past decade. This evolution is nearing the point of integration of Si-based photonics together with Si-CMOS for compact, high speed, high bandwidth, and cost-effective devices. However, due to the sensitive nature of passive and active photonic devices, variations inherent in wafer-based fabrication processes can lead to unacceptable levels of performance variation both within a give die and across a given wafer. Fully understanding the role …

Optomechanical Quantum Entanglement, Kahlil Y. Dixon

LSU Doctoral Dissertations

As classical technology approaches its limits, exploration of quantum technologies is critical. Quantum optics will be the basis of various cutting-edge research and applications in quantum technology. In particular, quantum optics quite efficacious when applied to quantum networks and the quantum internet. Quantum Optomechanics, a subfield of quantum optics, contains some novel methods for entanglement generation. These entanglement production methods exploit the noise re-encoding process, which is most often associated with creating unwanted phase noise in optical circuits. Using the adapted two-photon formalism and experimental results, we simulate (in an experimentally viable parameter space) optomechanical entanglement generation experiments. These simulations …

Investigating The Effect Of Self-Trapped Holes In The Current Gain Mechanism Of $ \Beta \Mathbf{-}{\Mathbf{Ga}}_{\Mathbf{2}}{\Mathbf{O}}_{\Mathbf{3}}$ Schottky Diode Photodetectors, Fati̇h Akyol

Turkish Journal of Physics

Monoclinic gallium oxide $(\beta\mathrm{-}{\mathrm{Ga}}_{\mathrm{2}}{\mathrm{O}}_{\mathrm{3}})$ has found great research interest in solar blind photodetector (SBP) applications due to its' bandgap $\mathrm{\sim}$4.85 eV and availability of high quality native crystal growth. Applications including missile guidance, flame detection, underwater/intersatellite communication and water purification systems require SBPs. $\beta\mathrm{-}{\mathrm{Ga}}_{\mathrm{2}}{\mathrm{O}}_{\mathrm{3}}$ SBPs with high responsivity values have been published indicating internal gain in these devices. The gain has been attributed to accumulation of self-trapped hole (STH) below Schottky metal which the lowers Schottky barrier in these devices based on some approximations rather than a proper device simulation. In this paper, technology computer-aided design (TCAD) simulation of $\beta\mathrm{-}{\mathrm{Ga}}_{\mathrm{2}}{\mathrm{O}}_{\mathrm{3}}$ …

Equations Of State For Warm Dense Carbon From Quantum Espresso, Derek J. Schauss

Theses and Dissertations

Warm dense plasma is the matter that exists, roughly, in the range of 10,000 to 10,000,000 Kelvin and has solid-like densities, typically between 0.1 and 10 grams per centimeter. Warm dense fluids like hydrogen, helium, and carbon are believed to make up the interiors of many planets, white dwarfs, and other stars in our universe. The existence of warm dense matter (WDM) on Earth, however, is very rare, as it can only be created with high-energy sources like a nuclear explosion. In such an event, theoretical and computational models that accurately predict the response of certain materials are thus very …

Eic Crab Cavity Multipole Analysis, Q. Wu, Y. Luo, B. Xiao, Subashini De Silva, J. A. Mitchell

Physics Faculty Publications

Crab cavities are specialized RF devices designed for colliders targeting high luminosities. It is a straightforward solution to retrieve head-on collision with crossing angle existing to fast separate both beams after collision. The Electron Ion Collider (EIC) has a crossing angle of 25 mrad, and will use local crabbing to minimize the dynamic aperture requirement throughout the rings. The current crab cavity design for the EIC lacks axial symmetry. Therefore, their higher order components of the fundamental deflecting mode have a potential of affecting the long-term beam stability. We present here the multipole analysis and preliminary particle tracking results from …

Redesign Of The Jefferson Lab -300 Kv Dc Photo-Gun For High Bunch Charge Operations, S.A.K. Wijethunga, J. Benesch, Jean R. Delayen, C. Hernandez-Garcia, Geoffrey A. Krafft, Gabriel Palacios-Serrano, M.A. Mamun, M. Poelker, R. Suleiman

Physics Faculty Publications

Production of high bunch charge beams for the ElectronIon Collider (EIC) is a challenging task. High bunch charge (a few nC) electron beam studies at Jefferson Lab using an inverted insulator DC high voltage photo-gun showed evidence of space charge limitations starting at 0.3 nC, limiting the maximum delivered bunch charge to 0.7 nC for beam at -225 kV, 75 ps (FWHM) pulse width, and 1.64 mm (rms) laser spot size. The low extracted charge is due to the modest longitudinal electric field (Ez) at the photocathode leading to beam loss at the anode and downstream beam pipe. To reach …

Effect Of A Mean Free Path On Nonlinear Losses Of Trapped Vortices Driven By A Rf Field, Manula Randhika Pathirana Walive Pathiranage, Alex Gurevich

Physics Faculty Publications

We report extensive numerical simulations on nonlinear dynamics of a trapped elastic vortex under rf field, and its dependence on electron mean free path li. Our calculations of the field-dependent residual surface resistance Ri(H) take into account the vortex line tension, the linear Bardeen-Stephen viscous drag and random distributions of pinning centers. We showed that Ri(H) decreases significantly at small fields as the material gets dirtier while showing field independent behavior at higher fields for clean and dirty limit. At low frequencies Ri(H) increases smoothly with the field amplitude at small H and levels off at higher fields. The mean …