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Improved In Situ Spring Constant Calibration For Colloidal Probe Atomic Force Microscopy, Sean P. Mcbride, Bruce M. Law
Improved In Situ Spring Constant Calibration For Colloidal Probe Atomic Force Microscopy, Sean P. Mcbride, Bruce M. Law
Dr. Sean P. McBride
In colloidal probe atomic force microscopy (AFM) surface forces cannot be measured without an accurate determination of the cantilever spring constant. The effective spring constant k depends upon the cantilever geometry and therefore should be measured in situ; additionally, k may be coupled to other measurement parameters. For example, colloidal probe AFM is frequently used to measure the slip length b at solid/liquid boundaries by comparing the measured hydrodynamic force with Vinogradova slip theory (V-theory). However, in this measurement k and b are coupled, hence, b cannot be accurately determined without knowing k to high precision. In this paper, a …