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Evaluation Of Yttrium-90 Positron Emission Tomography Dosimetry, Katherine N. Tapp
Evaluation Of Yttrium-90 Positron Emission Tomography Dosimetry, Katherine N. Tapp
Open Access Dissertations
Purpose: Radioembolization is a novel treatment which utilizes the liver's unique dual system blood supply to trap yttrium-90 (90Y) microspheres in microvasculature near liver tumors. Radioembolization dose planning and dosimetry are based on crude, inaccurate assumptions due to the lack of knowledge of patient specific 90Y microsphere distribution. In recent years, the very small 3.1867e-5 internal pair production decay branch of 90Y has been shown to allow for positron emission tomography (PET) imaging following radioembolization. This work explores the accuracy and limitation of 90Y PET imaging due to the extremely low signal to noise (SNR) …