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Full-Text Articles in Physical Sciences and Mathematics
Computational Analysis Of Type 3 Iodothyronine Deiodinase: Potential Inhibitors, Substrate Binding, And Dimer Structure, Eric Scott Marsan
Computational Analysis Of Type 3 Iodothyronine Deiodinase: Potential Inhibitors, Substrate Binding, And Dimer Structure, Eric Scott Marsan
Chemistry & Biochemistry Theses & Dissertations
Thyroid hormones (THs) in mammalian tissues are crucial for development and maintaining metabolic homeostasis. Iodothyronine deiodinases (Dios) remove iodines from THs by a selenocysteine (Sec) residue, which either activates or inactivates them. Halogen bonding (XB) has been proposed to describe the interaction between the Se and I atoms of the T4-Dio complex. Disruption of TH homeostasis by xenobiotics, such as polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) can cause deleterious effects on the endocrine system. Experimental studies have indicated that PBDEs and PCBs could disrupt TH homeostasis by inhibiting Dio through XB formation. However, no current quantitative study exists …
Oriented External Electric Field (Oeef) Tuning Of Unsubstituted Azoheteroarene Photoswitching Performance., Irma Avdic
Oriented External Electric Field (Oeef) Tuning Of Unsubstituted Azoheteroarene Photoswitching Performance., Irma Avdic
College of Arts & Sciences Senior Honors Theses
Azoheteroarenes are relatively new photoswitchable compounds, where one of the phenyl rings of an azobenzene molecule is replaced by a heteroaromatic five-membered ring. Although few studies have been performed, recent findings on methylated azoheteroarenes show that these photoswitches have great potential in various optically addressable applications. Thermal stability of molecular switches is one of the primary factors considered in the design process. For the purposes of quick information transmission in materials science, the thermal (Z – E) relaxation process should be as short as possible. On the other hand, molecular memory storage devices prefer long Z - E relaxation times. …