Physical Sciences and Mathematics Commons^™

Thermal Analysis In A Triple-Layered Skin Structure With Embedded Vasculature, Tumor, And Gold Nanoshells, Casey O. Orndorff

Doctoral Dissertations

In hyperthermia skin cancer treatment, the objective is to control laser heating of the tumor (target temperatures of 42-46 °C) so that the temperatures of the normal tissue surrounding the tumor remains low enough not to damage the normal tissue. However, obtaining accurate temperature distributions in living tissue related to hyperthermia skin cancer treatment without using an intruding sensor is a challenge. The objective of this dissertation research is to develop a mathematical model that can accurately predict the temperature distribution in the tumor region and surrounding normal tissue induced by laser irradiation. The model is based on a modified …