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Full-Text Articles in Physical Sciences and Mathematics
Cobalt Mediated Oxidative Cyclizations: The Diastereoselective Synthesis Of Trans-Tetrahydrofuran Rings, Cory D.N. Palmer
Cobalt Mediated Oxidative Cyclizations: The Diastereoselective Synthesis Of Trans-Tetrahydrofuran Rings, Cory D.N. Palmer
Electronic Thesis and Dissertation Repository
The Mukaiyama oxidative cyclization has been a major area of study within the Pagenkopf group and within the field of THF containing natural products. This document contains a brief discussion of the major divisions of THF synthesis; SN2, cycloadditions, and transition mediated strategies. The development of the Mukaiyama cyclization is described from the earliest applications of cobalt acac type ligand in Mukaiyama’s work to the initial discovery of the cyclization reactivity. Initial finding from the Mukaiyama group is shown, accompanied by its applications to the synthesis of mucosin, aplysiallene, and bullatacin. Previous attempts at improved catalyst design are …
Organometallic Materials: Ferroceno[C]Thiophenes And 1,2-Bisthienylmetallocenes, Surya R. Banks
Organometallic Materials: Ferroceno[C]Thiophenes And 1,2-Bisthienylmetallocenes, Surya R. Banks
Theses and Dissertations--Chemistry
Development of synthetic routes toward two general organometallic frameworks was undertaken. The first project involved synthetic attempts of substituted and unsubstituted ferroceno[c]thiophene while the second one was the synthesis of 1,2-dithienylmetallocenes. The long-term goal of this work is to lay the foundations for study of electronic, electrochromic, redox, and optical properties of thiophene-based materials integrated with organometallic systems such as ferrocene, ruthenocene and cymantrene. The synthetic pathway for the target molecule in the first project involved converting 1,2-bis(hydroxymethyl)ferrocene to 1,2-bis(thiouroniummethyl)ferrocene with thiourea under acidic conditions. Refluxing the salt in base followed by acidification resulted in 1,2-bis(mercaptomethyl)ferrocene, which is …