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Full-Text Articles in Physical Sciences and Mathematics
A Study On The Modifications Of [2.2]Paracyclophane And Their Effects On The Enantioselectivity Of The Copper Catalyzed Cyclopropanation Reaction, Yousef Dawoud
Honors Theses
The use of chiral [2.2]paracyclophane Schiff-base ligands has been shown to induce enantioselectivity in the copper catalyzed cyclopropanation of styrene with diazoesters. 1 Previous research by Dr. Masterson tested Schiff-base ligands based on 4- amino[2.2]paracyclophane with moderate enantioselectivity. In this project, the Schiff-base N- salicylidene-4-amino[2.2]paracyclophane, was modified by way of Grignard addition to the imine carbon and its enantioselective properties were explored with the copper catalyzed cyclopropanation. The methyl Grignard addition to N- salicylidene-4-amino[2.2]paracyclophane was successful in producing the amino alcohol and the amino alcohol was characterized. The amino alcohol was produced from the R enantiomer of the Schiff-base and …
Best Organic Chemistry Practices In The Midwest, Claire Van Der Bosch
Best Organic Chemistry Practices In The Midwest, Claire Van Der Bosch
Honors Theses
Organic Chemistry is a gateway course to a handful of courses in higher chemical education. Unfortunately, it is notorious for its high-fail, high-withdrawal, and high-drop rate and has a reputation for being time-consuming, with difficult concepts that are oftentimes new to students. It is often taught in a two-semester sequence, with the courses named Organic I and Organic II, and both courses have a lab component. At Western Michigan University, the fail rate for these two courses are 53.5% and 36.9%, respectively. Most higher education institutions are certified with the American Chemical Society (ACS) and given a skeleton of a …
Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova
Analysis Of Dl-Amino Acid Ratios In Eggshells Using Reverse Phase-High Pressure Liquid Chromatography, Gergana Milkova
Honors Theses
HPLC methodology was developed to determine the concentrations and ratios of D to L amino acids in emu and ostrich eggshells treated with heat at different temperatures . We aimed to determine an internal standard and how ratios were affected under different conditions. An HPLC method was determined that gave consistent retention times and satisfactory enantioseparation . Calibration curves for each amino acid were developed from single and multi-amino acid containing dilution series producing a model that most closely replicates the eggshell-extracted amino acids.
Generation And Reactions Of Cyclopropyl Vinylidene Carbenes, Nguyen Nhat Thu Le
Generation And Reactions Of Cyclopropyl Vinylidene Carbenes, Nguyen Nhat Thu Le
Honors Theses
This study aimed to generate cyclopropyl methyl vinylidene carbene and cyclopropyl phenyl vinylidene carbene via photochemical routes. The precursors to these two carbenes were synthesized from phenanthrene by a two-step procedure. However, these precursors could not be fully purified because the second step generated many side products with similar properties as the precursors. A crude sample of each precursor were photolyzed with UV light in the range of 315 to 400 nm. Vinylidene carbenes are known to rapidly rearrange into alkynes, so the formation of these cyclopropyl vinylidene carbenes was monitored through the formation of their rearrangement products, cyclopropyl methyl …