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Full-Text Articles in Physical Sciences and Mathematics
The Design, Synthesis And Application Of A Novel Class Of N-Heterocyclic Carbene Catalysts, Abigail Lynn Hubbard
The Design, Synthesis And Application Of A Novel Class Of N-Heterocyclic Carbene Catalysts, Abigail Lynn Hubbard
Graduate Theses and Dissertations
A copper carbenoid representative of a novel class of N-heterocyclic carbene (NHC) catalysts has been synthesized. This compound was characterized by X-ray crystallography and was found to confirm the rationale of our synthetic design: The C2-symmetric structure places four stereocenters in close proximity (<5Å) to the reactive site of the carbene via a trans-annular gearing effect. The copper carbenoid was found to catalyze the hydrosilylation of prochiral ketones with superb selectivity in high yield.
Dynamics And Catalytic Resolution Of Selected Chiral Organolithiums, Timothy Kum Beng
Dynamics And Catalytic Resolution Of Selected Chiral Organolithiums, Timothy Kum Beng
Graduate Theses and Dissertations
One of the most important developments of the last decade has been the emergence of new methods to dynamically resolve racemic organolithiums using stoichiometric amounts of the chiral ligand. When this concept is implemented successfully, it obviates the need for covalently attached chiral auxiliary based methods, asymmetric deprotonation, and asymmetric synthesis of a precursor stannane as ways to access enantioenriched organolithium compounds for use in asymmetric synthesis. Since certain electrophiles consume the chiral ligand, it is desirable to render this process catalytic in the chiral ligand.
As part of a larger study on the amenability of chiral organolithiums to a …