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Full-Text Articles in Physical Sciences and Mathematics
Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks
Substrate Analogs For Characterizing The Substrate Tolerance Of S. Pneumoniae Srta, Orion Banks
Graduate Student Symposium
Bacterial sortases have been widely studied for their usefulness in protein modification, however, the variable substrate specificity and activity between homologs of these enzymes is not yet fully characterized. To attempt to further understand sorting signal recognition, we are working towards a substrate bound structure of sortase A from Streptococcus pneumoniae (SrtApneu). This enzyme displays a wide tolerance for alternate amino acids within the canonical LPXTG sorting motif. Our strategy involves a non-cleavable substrate analog that can be docked into the active site, allowing for elucidation of a structure displaying the key contacts that allow the enzyme …
Keep Calm And Learn O-Chem, Hope Spargo
Keep Calm And Learn O-Chem, Hope Spargo
WWU Honors College Senior Projects
This project is an illustrated introductory guide to organic chemistry, featuring stories, metaphors, and fundamental concepts.