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The Ghrelin Receptor And Its Appetite For Highly Potent Ghrelin Analogues, Tyler J. Lalonde
The Ghrelin Receptor And Its Appetite For Highly Potent Ghrelin Analogues, Tyler J. Lalonde
Electronic Thesis and Dissertation Repository
The growth hormone secretagogue receptor-1a (GHS-R1a) is expressed in many human tissues, most notably the hypothalamus, and causes an increase in appetite upon activation by its endogenous ligand, ghrelin. GHS-R1a is differentially expressed in malignant compared to benign tumours. Therefore, there is an interest in developing GHS-R1a-targeted peptides as novel drugs to modulate signaling for diseases such as cancer cachexia and obesity and to image the receptor for disease diagnosis and following progression.
Chapter 2 discusses a fluorescently labelled ghrelin analogue for imaging GHS-R1a in ex vivo biopsy analysis and in vivo distribution studies. The analogue was created through side-chain …