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Full-Text Articles in Physical Sciences and Mathematics
Age-Related Sexual Dimorphism In Temporal Discrimination And In Adult-Onset Dystonia Suggests Gabaergic Mechanisms, John Butler, Ines M. Beiser, Laura Williams, Eavan Mcgovern, Fiona Molloy, Timothy Lynch, Dan G. Healy, Helena Moore, Richard Walsh, Richard B. Reilly, Sean O'Riordan, Cathal Walsh, Michael Hutchinson
Age-Related Sexual Dimorphism In Temporal Discrimination And In Adult-Onset Dystonia Suggests Gabaergic Mechanisms, John Butler, Ines M. Beiser, Laura Williams, Eavan Mcgovern, Fiona Molloy, Timothy Lynch, Dan G. Healy, Helena Moore, Richard Walsh, Richard B. Reilly, Sean O'Riordan, Cathal Walsh, Michael Hutchinson
Articles
Background: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants. Objectives: We assessed the distinctive features of age-related sexual dimorphism of (i) sex ratios in dystonia phenotypes and (ii) sexual dimorphism in temporal discrimination in unaffected relatives of cervical dystonia patients. Methods: We performed (i) a meta-regression analysis of the proportion of men in published cohorts of phenotypes of adult-onset dystonia in relation to their mean age of …
Exploring The Unknown: Electrophysiological And Behavioural Measures Of Visuospatial Learning, Brendan Quinlivan, John Butler, Abdur R. Ridwan, Ines Beiser, Laura Williams, Eavan Mcgovern, Sean O'Riordan, Michael Hutchinson, Richard B. Reilly
Exploring The Unknown: Electrophysiological And Behavioural Measures Of Visuospatial Learning, Brendan Quinlivan, John Butler, Abdur R. Ridwan, Ines Beiser, Laura Williams, Eavan Mcgovern, Sean O'Riordan, Michael Hutchinson, Richard B. Reilly
Articles
Visuospatial memory describes our ability to temporarily store and manipulate visual and spatial information, and is employed for a wide variety of complex cognitive tasks. Here, a visuospatial learning task requiring fine motor control is employed to investigate visuospatial learning in a group of typically developing adults. Electrophysiological and behavioural data are collected during a target location task under two experimental conditions: Target Learning and Target Cued. Movement times (MTs) are employed as a behavioural metric of performance, while dynamic P3b amplitudes and power in the alpha band (approximately 10 Hz) are explored as electrophysiological metrics during visuospatial learning. Results …