Physical Sciences and Mathematics Commons^™

The Search For Optimal Oxygen Saturation Targets In Critically Ill: Patients Observational Data From Large Icu Databases, Willem Van Den Boom, Michael Hoy, Jagadish Sankaran, Mengru Liu, Haroun Chahed, Mengling Feng, Kay Choong See

Research Collection School Of Computing and Information Systems

Background: Although low oxygen saturations are generally regarded as deleterious, recent studies in ICU patients have shown that a liberal oxygen strategy increases mortality. However, the optimal oxygen saturation target remains unclear. The goal of this study was to determine the optimal range by using real-world data. Methods: Replicate retrospective analyses were conducted of two electronic medical record databases: the eICU Collaborative Research Database (eICU-CRD) and the Medical Information Mart for Intensive Care III database (MIMIC). Only patients with at least 48 h of oxygen therapy were included. Nonlinear regression was used to analyze the association between median pulse oximetry-derived …