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Full-Text Articles in Physical Sciences and Mathematics
Epidemiology Of Latency And Relapse In Plasmodium Vivax Malaria, Andrew A. Lover
Epidemiology Of Latency And Relapse In Plasmodium Vivax Malaria, Andrew A. Lover
Andrew Lover
Malaria is a major contributor to health burdens throughout the regions where it is endemic. Historically, it was believed that there was limited morbidity and essentially no mortality associated with Plasmodium vivax; however, evidence from diverse settings now suggests that infections with P. vivax can be both severe and fatal. This awareness has highlighted a critical gap: the vast majority of research has been directed towards P. falciparum, leading to a decades-long neglect of epidemiological and clinical studies of P. vivax. There exists a large body of historical data on human experimental infections with P. vivax; these studies in controlled …
Considerations For Comprehensive Analyses Of Sporozoite-Based Controlled Human Malaria Infection Studies, Andrew A. Lover
Considerations For Comprehensive Analyses Of Sporozoite-Based Controlled Human Malaria Infection Studies, Andrew A. Lover
Andrew Lover
There has been renewed interest in the use of sporozoite-based approaches for controlled human malaria infections (CHMIs), and several sets of human challenge studies have recently completed. A study undertaken in Tanzania and published in 2014 found dose dependence between 10,000 and 25,000 sporozoite doses, as well as divergent times-to-parasitemia relative to earlier studies in European volunteers, with important implications for planning future studies. Analysis of time-to-event data has had extensive development in recent years, but these methods have had limited exposure outside biostatistics. Expansion of the published analyses to include recent methodological approaches optimized for the types of data …
Short Report: Study Variability In Recent Human Challenge Experiments With Plasmodium Falciparum Sporozoites (Pfspz Challenge), Andrew A. Lover
Short Report: Study Variability In Recent Human Challenge Experiments With Plasmodium Falciparum Sporozoites (Pfspz Challenge), Andrew A. Lover
Andrew Lover
There has been renewed interest in the use of sporozoite-based approaches for malaria vaccination and controlled human infections, and several sets of human challenge studies have recently completed. A study undertaken in Tanzania and published in 2014 found dose-dependence between 10,000 and 25,000 sporozoite doses, as well as divergent times-to-parasitemia relative to earlier studies in European volunteers. However, this analysis shows that these conclusions are based upon suboptimal analytical methods; with more optimal analysis, there is no evidence for dose-dependence within this dose range; and more importantly, no evidence for differences in event times between Dutch and Tanzanian study sites. …