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Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences

2015

Florida International University

Articles 1 - 5 of 5

Full-Text Articles in Physical Sciences and Mathematics

Organometallic Rhenium Dyes For Nitric Oxide Detection And Imaging, Lissette I. Lozano-Lewis Nov 2015

Organometallic Rhenium Dyes For Nitric Oxide Detection And Imaging, Lissette I. Lozano-Lewis

FIU Electronic Theses and Dissertations

The importance of sensing Nitric Oxide (NO) in physiology and medicine has led us to explore the reactivity of NO with organometallic Re dyes. Rhenium complexes were synthesized with the ability to react with NO and sense it under physiological conditions. Fluorescent 1,10-phenantroline complexes (phen)Re(PPh3)(CO)2OSO2CF3 (1) and (phen)Re(CH3CN)(CO)2OSO2CF3 (3) can sense NO in the range of 10 - 150 mM showing a decrease in fluorescence response at 514 nm and 532 nm respectively, upon NO-donor addition (lexc = 360 nm). (phen)Re(THF)(CO)2OSO2CF …

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Integrated Bioinformatics, Environmental Epidemiologic And Genomic Approaches To Identify Environmental And Molecular Links Between Endometriosis And Breast Cancer, Deodutta Roy, Marisa L. Morgan, Changwon Yoo, Alok Deoraj, Sandhya Roy, Vijay Kumar Yadav, Mohannad Garoub, Hamza Assaggaf, Mayur Doke Oct 2015

Integrated Bioinformatics, Environmental Epidemiologic And Genomic Approaches To Identify Environmental And Molecular Links Between Endometriosis And Breast Cancer, Deodutta Roy, Marisa L. Morgan, Changwon Yoo, Alok Deoraj, Sandhya Roy, Vijay Kumar Yadav, Mohannad Garoub, Hamza Assaggaf, Mayur Doke

Department of Biostatistics Faculty Publications

We present a combined environmental epidemiologic, genomic, and bioinformatics approach to identify: exposure of environmental chemicals with estrogenic activity; epidemiologic association between endocrine disrupting chemical (EDC) and health effects, such as, breast cancer or endometriosis; and gene-EDC interactions and disease associations. Human exposure measurement and modeling confirmed estrogenic activity of three selected class of environmental chemicals, polychlorinated biphenyls (PCBs), bisphenols (BPs), and phthalates. Meta-analysis showed that PCBs exposure, not Bisphenol A (BPA) and phthalates, increased the summary odds ratio for breast cancer and endometriosis. Bioinformatics analysis of gene-EDC interactions and disease associations identified several hundred genes that were altered by …

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Analysis Of Synthetic Cannabinoids By Direct Analysis In Real Time Quadrupole Time-Of-Flight Mass Spectrometry And Gas Chromatography Quadrupole Time-Of-Flight Mass Spectrometry, Tyler S. Torbet Jun 2015

Analysis Of Synthetic Cannabinoids By Direct Analysis In Real Time Quadrupole Time-Of-Flight Mass Spectrometry And Gas Chromatography Quadrupole Time-Of-Flight Mass Spectrometry, Tyler S. Torbet

FIU Electronic Theses and Dissertations

The aim of this study was to investigate the utility of direct analysis in real time quadrupole time-of-flight mass spectrometry and gas chromatography quadrupole time-of-flight mass spectrometry in the analysis of 162 different synthetic cannabinoids. Direct analysis in real time quadrupole time-of-flight mass spectrometry is shown to be a rapid and accurate analytical method for synthetic cannabinoids. Spectra can be generated with less than 1.5 ng of the drug in under a minute and be successfully searched against previously generated ESI-QTOF libraries in most cases (118/130 drugs tested) as well as can also be applied to the identification of synthetic …

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Genetic Associations Of Ppargc1a With Type 2 Diabetes: Differences Among Populations With African Origins, Amanpreet K. Cheema, Tan Li, Juan P. Liuzzi, Gustavo G. Zarini, Mehmet T. Dorak, Fatma G. Huffman Mar 2015

Genetic Associations Of Ppargc1a With Type 2 Diabetes: Differences Among Populations With African Origins, Amanpreet K. Cheema, Tan Li, Juan P. Liuzzi, Gustavo G. Zarini, Mehmet T. Dorak, Fatma G. Huffman

Department of Biostatistics Faculty Publications

The aim of this study was to assess the differences in correlation of PPARGC1A polymorphisms with type 2 diabetes (T2D) risk in adults of African origins: African Americans and Haitian Americans. The case-control study consisted of >30 years old, self-identified Haitian Americans (n = 110 cases and n = 116 controls) and African Americans (n = 124 cases and n = 122 controls) living in South Florida with and without T2D. Adjusted logistic regression indicated that both SNP rs7656250 (OR = 0.22, P = 0.005) and rs4235308 (OR = 0.42, P = 0.026) showed protective association with T2D in Haitian …

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Conjugated Polymer Nanoparticles For Biological Labeling And Delivery, Eladio A. Mendez Mar 2015

Conjugated Polymer Nanoparticles For Biological Labeling And Delivery, Eladio A. Mendez

FIU Electronic Theses and Dissertations

Cancer remains one of the world’s most devastating diseases, with more than 10 million new cases every year. However, traditional treatments have proven insufficient for successful medical management of cancer due to the chemotherapeutics’ difficulty in achieving therapeutic concentrations at the target site, non-specific cytotoxicity to normal tissues, and limited systemic circulation lifetime. Although, a concerted effort has been placed in developing and successfully employing nanoparticle(NP)-based drug delivery vehicles successfully mitigate the physiochemical and pharmacological limitations of chemotherapeutics, work towards controlling the subcellular fate of the carrier, and ultimately its payload, has been limited. Because efficient therapeutic action requires drug …

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