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Full-Text Articles in Physical Sciences and Mathematics
Identification Of Receptor Ligands In Apo B100 Reveals Potential Functional Domains, Juan Guevara Jr., Jamie Romo Jr., Ernesto Hernandez, Natalia Valentinova Guevara
Identification Of Receptor Ligands In Apo B100 Reveals Potential Functional Domains, Juan Guevara Jr., Jamie Romo Jr., Ernesto Hernandez, Natalia Valentinova Guevara
Physics and Astronomy Faculty Publications and Presentations
LDL, VLDL and other members of the low-density lipoparticles (LLPs) enter cells through a large family of receptors. The actual receptor ligand(s) in apolipoprotein B100, one of the main proteins of LLP, remain(s) unknown. The objective of this study was to identify true receptor ligand(s) in apo B100, a molecule of 4,563 residues. Apo B100 contains 33 analogues of Cardin-Weintraub Arginine/Lysine-based receptor ligand motifs and shares key Lysine motifs and sequence similarity with the LDL receptor-associated protein, RAP, MESD, and heat shock proteins. Eleven FITC-labeled synthetic peptides of 21 – 42 residues, with at least one ligand, were tested for …
Vitamin D: Controversy Cancer And Beyond, Cristian J. Rosales, Debasish Bandyopadhyay
Vitamin D: Controversy Cancer And Beyond, Cristian J. Rosales, Debasish Bandyopadhyay
Chemistry Faculty Publications and Presentations
Vitamins are an essential part to wellbeing. This was not something always known however, as the Germ theory was the accepted thesis of the 18th century. It was found that certain accessory factors helped mitigate and even cure these diseases such as beriberi, scurvy, and rickets. Accessory factors, later coined vitamins by Casimir Funk, are an essential constituent of the human diet. Vitamin D is technically not a vitamin but functions as a steroid hormone whose most well-known purpose is calcification of the human skeleton. This helps prevent osteomalacia in adults and rickets, a serious problem in children due to …
Glutathione: A Small Molecule With Big Sense, Cristina E. Raya, Debasish Bandyopadhyay
Glutathione: A Small Molecule With Big Sense, Cristina E. Raya, Debasish Bandyopadhyay
Chemistry Faculty Publications and Presentations
Glutathione, a peptide found in microbes, plants and animals including human plays a key role in maintaining healthy cells. The peptide exists in both reduced and oxidized forms. Synthesis of GSH occurs in the cytosol of cells, and the extent of glutathione synthesis relies on various factors, such as amino acid availability, protein activity etc. Once synthesized, glutathione exists in both forms: oxidized (GSSG) and reduced (GSH). Oxidized glutathione characterized by its disulfide linkage. On the other hand, presence of a thiol group characterizes the reduced glutathione. This thiol makes the tripeptide an essential component of health; it makes glutathione …
Source-Specific Pollution Exposure And Associations With Pulmonary Response In The Atlanta Commuters Exposure Studies, Jenna R. Krall, Chandresh N. Ladva, Armistead G. Russell, Rachel Golan, Xing Peng, Guoliang Shi, Roby Greenwald, Amit U. Raysoni, Lance A. Waller, Jeremy A. Sarnat
Source-Specific Pollution Exposure And Associations With Pulmonary Response In The Atlanta Commuters Exposure Studies, Jenna R. Krall, Chandresh N. Ladva, Armistead G. Russell, Rachel Golan, Xing Peng, Guoliang Shi, Roby Greenwald, Amit U. Raysoni, Lance A. Waller, Jeremy A. Sarnat
School of Earth, Environmental, and Marine Sciences Faculty Publications and Presentations
Concentrations of traffic-related air pollutants are frequently higher within commuting vehicles than in ambient air. Pollutants found within vehicles may include those generated by tailpipe exhaust, brake wear, and road dust sources, as well as pollutants from in-cabin sources. Sourcespecific pollution, compared to total pollution, may represent regulation targets that can better protect human health. We estimated source-specific pollution exposures and corresponding pulmonary response in a panel study of commuters. We used constrained positive matrix factorization to estimate source-specific pollution factors and, subsequently, mixed effects models to estimate associations between source-specific pollution and pulmonary response. We identified four pollution factors …