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Full-Text Articles in Physical Sciences and Mathematics
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov
Doctoral Dissertations
Reactive chemistries for protein chemical modification play an instrumental role in chemical biology, proteomics, and therapeutics. Depending on the application, the selectivity of these modifications can range from precise modification of an amino acid sequence by genetic manipulation of protein expression machinery to a stochastic modification of lysine residues on the protein surface. Ligand-Directed (LD) chemistry is one of the few methods for targeted modification of endogenous proteins without genetic engineering. However, current LD strategies are limited by stringent amino acid selectivity. To bridge this gap, this thesis focuses on the development of highly reactive LD Triggerable Michael Acceptors (LD-TMAcs) …
Evidence Assisted Learning For Clinical Decision Support Systems, Bhanu Pratap Singh Rawat
Evidence Assisted Learning For Clinical Decision Support Systems, Bhanu Pratap Singh Rawat
Doctoral Dissertations
Clinical decision support systems (CDSS) provide intelligently filtered knowledge and patient-specific and population information to the clinicians, nursing staff and healthcare professionals. CDSS can significantly improve the quality, safety, efficiency and effectiveness of health care. Over the last decade, American hospitals have adopted electronic health records (EHRs) widely resulting in a massive collection of clinical notes such as admission notes, physician notes, nursing notes and discharge summaries. For the past couple of decades, most of the work in CDSS has been focused on developing knowledge-based systems using structured data such as medications and ICD codes. In contrast, the EHR notes …