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Full-Text Articles in Physical Sciences and Mathematics
Data-Driven Analysis Of Drug And Substance Abuse Rates Across The Varying Regions In The United States Of America, Reem Saleh
University Honors Theses
Drugs and substance abuse is one of the leading causes of death for adolescents in the United States. The consequences of using these drugs are profound and can cause both damage to one's physical and psychological health. The rates of drug abuse in the United States continue to increase over the years. This paper analyzes the trends in rates of drug abuse in the four regions in the United States. It looks at the rates in cocaine, cigarettes, marijuana, and tobacco. A preliminary analysis was done to look at the trend in rates followed by an ARIMA time series model …
Soft Lithographic Replication Of High Length-Scale Micropillars From Laser-Ablated Fused-Silica Templates, Jason Pitts
Soft Lithographic Replication Of High Length-Scale Micropillars From Laser-Ablated Fused-Silica Templates, Jason Pitts
University Honors Theses
Soft lithography is a well-established route to wafer-scale reproduction of micro- and nanoscale features in a wide variety of materials. Nevertheless, micron length scales have yet to be explored, despite the potential utility of such structures. Here, polymer micropillars of 6-12 μm length, approximately 0.5-1.5 μm wide at 10 μm spacing are reproduced from a polydimethylsiloxane (PDMS) mold made from patterned cellulose acetate (CA). The patterned CA was cast from a rigid fused silica template machined by a pulsed femtosecond laser. Pore topographic features were successfully reproduced in Norland Optical Adhesive (NOA), polycaprolactone (PCL), Nafion, acrylonitrile butadiene styrene (ABS), and …
Inhibition Of Cancer Causing Genes Through The Delivery Of Omomyc In Anti-Myc Therapy: A Systematic Review, Angie Mcgraw
Inhibition Of Cancer Causing Genes Through The Delivery Of Omomyc In Anti-Myc Therapy: A Systematic Review, Angie Mcgraw
University Honors Theses
A systematic review of the available studies on the interference of OmoMyc with Myc's function in cancerous cells is presented. Myc is a transcription factor that regulates cellular processes such as apoptosis, proliferation, and differentiation. However, Myc is often overexpressed in a variety of cancers, resulting in abnormal growth of cancer cells. Although the inhibition of Myc has been highly desired, it remained a challenge due to its undruggable characteristics. Attempts to inhibit Myc have involved the usage of small-molecules, but these attempts have failed, causing adverse effects and incomplete inhibition of Myc. Despite promising preclinical studies of OmoMyc, it …