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- Cancer (1)
- Chemotherapy (1)
- Compartmental model (1)
- Digital signal processing (1)
- HIV infections (1)
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- Humans (1)
- Internet (1)
- Jeffs phenomenon (1)
- Mathematical modeling (1)
- Medical tests (1)
- Natural language processing (1)
- Ontologies (1)
- Sensitivity analysis (1)
- Software libraries (1)
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- Tumor (1)
- Unified modeling language (1)
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- Wodarz-Nowak model (1)
Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
Meeting Medical Terminology Needs: The Ontology-Enhanced Medical Concept Mapper, Gondy Leroy, Hsinchun Chen
Meeting Medical Terminology Needs: The Ontology-Enhanced Medical Concept Mapper, Gondy Leroy, Hsinchun Chen
CGU Faculty Publications and Research
This paper describes the development and testing of the Medical Concept Mapper, a tool designed to facilitate access to online medical information sources by providing users with appropriate medical search terms for their personal queries. Our system is valuable for patients whose knowledge of medical vocabularies is inadequate to find the desired information, and for medical experts who search for information outside their field of expertise. The Medical Concept Mapper maps synonyms and semantically related concepts to a user's query. The system is unique because it integrates our natural language processing tool, i.e., the Arizona (AZ) Noun Phraser, with human-created …
Modeling Control Of Hiv Infection Through Structured Treatment Interruptions With Recommendations For Experimental Protocol, Shannon Kubiak, Heather Lehr, Rachel Levy, Todd Moeller, Albert Parker, Edward Swim
Modeling Control Of Hiv Infection Through Structured Treatment Interruptions With Recommendations For Experimental Protocol, Shannon Kubiak, Heather Lehr, Rachel Levy, Todd Moeller, Albert Parker, Edward Swim
All HMC Faculty Publications and Research
Highly Active Anti-Retroviral Therapy (HAART) of HIV infection has significantly reduced morbidity and mortality in developed countries. However, since these treatments can cause side effects and require strict adherence to treatment protocol, questions about whether or not treatment can be interrupted or discontinued with control of infection maintained by the host immune system remain to be answered. We present sensitivity analysis of a compartmental model for HIV infection that allows for treatment interruptions, including the sensitivity of the compartments themselves to our parameters as well as the sensitivity of the cost function used in parameter estimation. Recommendations are made about …
A Mathematical Tumor Model With Immune Resistance And Drug Therapy: An Optimal Control Approach, Lisette G. De Pillis, Ami E. Radunskaya
A Mathematical Tumor Model With Immune Resistance And Drug Therapy: An Optimal Control Approach, Lisette G. De Pillis, Ami E. Radunskaya
All HMC Faculty Publications and Research
We present a competition model of cancer tumor growth that includes both the immune system response and drug therapy. This is a four-population model that includes tumor cells, host cells, immune cells, and drug interaction. We analyze the stability of the drug-free equilibria with respect to the immune response in order to look for target basins of attraction. One of our goals was to simulate qualitatively the asynchronous tumor-drug interaction known as “Jeffs phenomenon.” The model we develop is successful in generating this asynchronous response behavior. Our other goal was to identify treatment protocols that could improve standard pulsed chemotherapy …