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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Nobiletin Affects Circadian Rhythms And Oncogenic Characteristics In A Cell-Dependent Manner, Sujeewa S. Lellupitiyage Don, Kelly L. Robertson, Hui-Hsien Lin, Caroline Labriola, Mary E. Harrington, Stephanie R. Taylor, Michelle E. Farkas
Nobiletin Affects Circadian Rhythms And Oncogenic Characteristics In A Cell-Dependent Manner, Sujeewa S. Lellupitiyage Don, Kelly L. Robertson, Hui-Hsien Lin, Caroline Labriola, Mary E. Harrington, Stephanie R. Taylor, Michelle E. Farkas
Psychology: Faculty Publications
The natural product nobiletin is a small molecule, widely studied with regard to its therapeutic effects, including in cancer cell lines and tumors. Recently, nobiletin has also been shown to affect circadian rhythms via their enhancement, resulting in protection against metabolic syndrome. We hypothesized that nobiletin’s anti-oncogenic effects, such as prevention of cell migration and formation of anchorage independent colonies, are correspondingly accompanied by modulation of circadian rhythms. Concurrently, we wished to determine whether the circadian and anti-oncogenic effects of nobiletin differed across cancer cell lines. In this study, we assessed nobiletin’s circadian and therapeutic characteristics to ascertain whether these …
Circada: Shiny Apps For Exploration Of Experimental And Synthetic Circadian Time Series With An Educational Emphasis, Lisa Cenek, Liubou Klindziuk, Cindy Lopez, Eleanor Mccartney, Blanca Martin Burgos, Selma Tir, Mary E. Harrington, Tanya L. Leise
Circada: Shiny Apps For Exploration Of Experimental And Synthetic Circadian Time Series With An Educational Emphasis, Lisa Cenek, Liubou Klindziuk, Cindy Lopez, Eleanor Mccartney, Blanca Martin Burgos, Selma Tir, Mary E. Harrington, Tanya L. Leise
Psychology: Faculty Publications
Circadian rhythms are daily oscillations in physiology and behavior that can be assessed by recording body temperature, locomotor activity, or bioluminescent reporters, among other measures. These different types of data can vary greatly in waveform, noise characteristics, typical sampling rate, and length of recording. We developed 2 Shiny apps for exploration of these data, enabling visualization and analysis of circadian parameters such as period and phase. Methods include the discrete wavelet transform, sine fitting, the Lomb-Scargle periodogram, autocorrelation, and maximum entropy spectral analysis, giving a sense of how well each method works on each type of data. The apps also …