Physical Sciences and Mathematics Commons^™

Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo

Nima Rahbar

This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …