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Prefrontal White Matter Pathology In Air Pollution Exposed Mexico City Young Urbanites And Their Potential Impact On Neurovascular Unit Dysfunction And The Development Of Alzheimer’S Disease, Partha S. Mukherjee

Mathematics Faculty Publications and Presentations

Millions of urban children are chronically exposed to high concentrations of air pollutants, i.e., fine particulate matter (PM_2.5) and ozone, associated with increased risk for Alzheimer’s disease. Compared with children living with clear air those in Mexico City (MC) exhibit systemic, brain and intrathecal inflammation, low CSF Aβ ₄₂, breakdown of the BBB, attention and short-term memory deficits, prefrontal white matter hyperintensities, damage to epithelial and endothelial barriers, tight junction and neural autoantibodies, and Alzheimer and Parkinson's hallmarks. The prefrontal white matter is a target of air pollution. We examined by light and electron microscopy the prefrontal …