Physical Sciences and Mathematics Commons^™

An Axiomatic Approach To The Non-Linear Theory Of Generalized Functions And Consistency Of Laplace Transforms, Todor D. Todorov

Mathematics

We offer an axiomatic definition of a differential algebra of generalized functions over an algebraically closed non-Archimedean field. This algebra is of Colombeau type in the sense that it contains a copy of the space of Schwartz distributions. We study the uniqueness of the objects we define and the consistency of our axioms. Next, we identify an inconsistency in the conventional Laplace transform theory. As an application we offer a free of contradictions alternative in the framework of our algebra of generalized functions. The article is aimed at mathematicians, physicists and engineers who are interested in the non-linear theory of …

Completeness Of The Leibniz Field And Rigorousness Of Infinitesimal Calculus, James F. Hall, Todor D. Todorov

Mathematics

We present a characterization of the completeness of the field of real numbers in the form of a collection of ten equivalent statements borrowed from algebra, real analysis, general topology and non-standard analysis. We also discuss the completeness of non-Archimedean fields and present several examples of such fields. As an application we exploit one of our results to argue that the Leibniz infinitesimal calculus in the 18^th century was already a rigorous branch of mathematics – at least much more rigorous than most contemporary mathematicians prefer to believe. By advocating our particular historical point of view, we hope to …

Strategic Treatment Interruptions During Imatinib Treatment Of Chronic Myelogenous Leukemia, Dana C. Paquin, Peter S. Kim, Peter P. Lee, Doron Levy

Mathematics

Although imatinib is an effective treatment for chronic myelogenous leukemia (CML), and nearly all patients treated with imatinib attain some form of remission, imatinib does not completely eliminate leukemia. Moreover, if the imatinib treatment is stopped, most patients eventually relapse (Cortes et al. in Clin. Cancer Res. 11:3425–3432, 2005). In Kim et al. (PLoS Comput. Biol. 4(6):e1000095, 2008), the authors presented a mathematical model for the dynamics of CML under imatinib treatment that incorporates the anti-leukemia immune response. We use the mathematical model in Kim et al. (PLoS Comput. Biol. 4(6):e1000095, 2008) to study and numerically simulate strategic treatment interruptions …

Another Proof Of The Existence A Dedekind Complete Totally Ordered Field, James F. Hall, Todor D. Todorov

Mathematics

We describe the Dedekind cuts explicitly in terms of non-standard rational numbers. This leads to another construction of a Dedekind complete totally ordered field or, equivalently, to another proof of the consistency of the axioms of the real numbers. We believe that our construction is simpler and shorter than the classical Dedekind construction and Cantor construction of such fields assuming some basic familiarity with non-standard analysis.

Planning And Analysis Of Measurement Reliability Studies, S H. Steiner, Nathaniel Stevens, R Browne, R J. Mackay

Mathematics

In the traditional plan for assessing the reliability of a measurement system, a number of raters each measure the same group of subjects. If the system has a large number of raters, we recommend a new set of plans that have two advantages over the traditional plan. First, the proposed plans provide greater precision for estimating the intraclass correlation coefficient with the same total number of measurements. Second, the plans are flexible and can be adapted to constraints on the number of times any subject can be assessed or the number of times any rater can make an assessment. We …

Monitoring Radiation Use In Cardiac Fluoroscopy Imaging Procedures, Nathaniel Stevens, S H. Steiner, I R. Smith, R J. Mackay

Mathematics

Objective: Timely identification of systematic changes in radiation delivery of an imaging system can lead to a reduction in risk for the patients involved. However, existing quality assurance programs involving the routine testing of equipment performance using phantoms are limited in their ability to effectively carry out this task. To address this issue we propose the implementation of an ongoing monitoring process that utilizes procedural data to identify unexpected large or small radiation exposures for individual patients, as well as to detect persistent changes in the radiation output of imaging platforms.

Methods: Data used in this study were obtained from …

On The Equivariant Cohomology Of Rotation Groups And Stiefel Manifolds, William Kronholm

Mathematics

In this paper, we compute the RO(Z/2)-graded equivariant cohomology of rotation groups and Stiefel manifolds with particular involutions.