Physical Sciences and Mathematics Commons^™

Diet And Lifetyle Factors Associated With Mirna Expression In Colorectal Tissue, Martha L. Slattery, Jennifer S. Herrick, Lila E. Mullany, John R. Stevens, Roger K. Wolff

Mathematics and Statistics Faculty Publications

MicroRNAs (miRNAs) are small non-protein-coding RNA molecules that regulate gene expression. Diet and lifestyle factors have been hypothesized to be involved in the regulation of miRNA expression. In this study it was hypothesized that diet and lifestyle factors are associated with miRNA expression. Data from 1,447 cases of colorectal cancer to evaluate 34 diet and lifestyle variables using miRNA expression in normal colorectal mucosa as well as for differential expression between paired carcinoma and normal tissue were used. miRNA data were obtained using an Agilent platform. Multiple comparisons were adjusted for using the false discovery rate q-value. There were 250 …

Managing The Spread Of Alfalfa Stem Nematodes (Ditylenchus Dipsaci): The Relationship Between Crop Rotation Periods And Pest Re-Emergence, S. Jordan, Claudia Nischwitz, R. Ramirez, Luis F. Gordillo

Mathematics and Statistics Faculty Publications

Alfalfa is a critical cash/rotation crop in the western region of the United States, where it is common to find crops affected by the alfalfa stem nematode (Ditylenchus dipsaci). Understanding the spread dynamics associated with this pest would allow growers to design better management programs and farming practices. This understanding is of particular importance given that there are no nematicides available against alfalfa stem nematodes and control strategies largely rely on crop rotation to non-host crops or by planting resistant varieties of alfalfa. In this paper we present a basic host-parasite model that describes the spread of the …

On The Geodesic Centers Of Polygonal Domains, Haitao Wang

Computer Science Faculty and Staff Publications

In this paper, we study the problem of computing Euclidean geodesic centers of a polygonal domain P of n vertices. We give a necessary condition for a point being a geodesic center. We show that there is at most one geodesic center among all points of P that have topologically-equivalent shortest path maps. This implies that the total number of geodesic centers is bounded by the size of the shortest path map equivalence decomposition of P, which is known to be O(n^{10}). One key observation is a pi-range property on shortest path lengths when points are moving. With these observations, …

Modeling Zombie Outbreaks: A Problem-Based Approach To Improving Mathematics One Brain At A Time, Matthew Lewis, James A. Powell

Mathematics and Statistics Faculty Publications

A great deal of educational literature has focused on problem-based learning (PBL) in mathematics at the primary and secondary level, but arguably there is an even greater need for PBL in college math courses. We present a project centered around the Humans vs. Zombies moderated tag game played on the USU campus. We discuss the project in the context of an undergraduate differential equations course and discuss how the project is launched. We highlight examples of students mathematical models along with their verbal and written responses as well as discussing assessment and student learning. Results are discussed in the context …

Ε-Kernel Coresets For Stochastic Points, Haitao Wang, Lingxiao Huang, Jian Li, Jeff Mark Phillips

Computer Science Faculty and Staff Publications

With the dramatic growth in the number of application domains that generate probabilistic, noisy and uncertain data, there has been an increasing interest in designing algorithms for geometric or combinatorial optimization problems over such data. In this paper, we initiate the study of constructing epsilon-kernel coresets for uncertain points. We consider uncertainty in the existential model where each point's location is fixed but only occurs with a certain probability, and the locational model where each point has a probability distribution describing its location. An epsilon-kernel coreset approximates the width of a point set in any direction. We consider approximating the …

How The Magnitude Of Prey Genetic Variation Alters Predator-Prey Eco-Evolutionary Dynamics, Michael H. Cortez

Mathematics and Statistics Faculty Publications

Evolution can alter the stability and dynamics of ecological communities; for example, prey evolution can drive cyclic dynamics in predator-prey systems that are not possible in the absence of evolution. However, it is unclear how the magnitude of additive genetic variation in the evolving species mediates those effects. In this study, I explore how the magnitude of prey additive genetic variation determines what effects prey evolution has on the dynamics and stability of predator-prey systems. I use linear stability analysis to decompose the stability of a general eco-evolutionary predator-prey model into components representing the stabilities of the ecological and evolutionary …

A Proof Of Concept Study Of Function-Based Statistical Analysis Of Fnirs Data: Syntax Comprehension In Children With Specific Language Impairment Compared To Typically-Developing Controls, Matthew D. Meng, Nicholas J. Wan, Joseph M. Baker, James Montgomery, Julia L. Evans, Ronald Gillam

Mathematics and Statistics Faculty Publications

Functional near infrared spectroscopy (fNIRS) is a neuroimaging techonology that enables investigators to indirectly monitor brain activity in vivo through relative changes in the concentration of oxygenated and deoxygenated hemoglobin. One of the key features of fNIRS is its superior temporal resolution, with dense measurements over very short periods of time (100ms increments). Unfortunately, most statistical analysis approaches in the existing literature have not fully utilized the high temporal resolution of fNIRS. For example, many analysis procedures are based on linearity assumptions that only extract partial information, thereby neglecting the overall dynamic trends in fNIRS trajectories. The main goal of …

Hydra Effects In Stable Communities And Their Implications For System Dynamics, Michael H. Cortez, Peter A. Abrams

Mathematics and Statistics Faculty Publications

A hydra effect occurs when the mean density of a species increases in response to greater mortality. We show that, in a stable multispecies system, a species exhibits a hydra effect only if maintaining that species at its equilibrium density destabilizes the system. The stability of the original system is due to the responses of the hydra-effect species to changes in the other species’ densities. If that dynamical feedback is removed by fixing the density of the hydra-effect species, large changes in the community make-up (including the possibility of species extinction) can occur. This general result has several implications: (1) …

Yeast For Mathematicians - A Ferment Of Discovery, Matthew Lewis, James A. Powell

Mathematics and Statistics Faculty Publications

In addition to the memorization, algorithmic skills and vocabulary which are the default focus in many mathematics classrooms, professional mathematicians are expected to creatively apply known techniques, construct new mathematical approaches and communicate with and about mathematics. We propose that students can learn these professional, higher-level skills through Laboratory Experiences in Mathematical Biology which put students in the role of mathematics researcher creating mathematics to describe and understand biological data. Here we introduce a laboratory experience centered on yeast (Saccharomyces cerevisiae) growing in a small capped flask with a jar to collect carbon dioxide created during yeast growth …

Expression Profiles Of Mirna Subsets Distinguish Human Colorectal Carcinoma And Normal Colonic Mucosa, Daniel F. Pellatt, John R. Stevens, Roger K. Wolff, Lila E. Mullany, Jennifer S. Herrick, Wade Samowitz, Martha L. Slattery

Mathematics and Statistics Faculty Publications

OBJECTIVES: MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that are commonly dysregulated in colorectal tumors. The objective of this study was to identify smaller subsets of highly predictive miRNAs.

METHODS: Data come from population-based studies of colorectal cancer conducted in Utah and the Kaiser Permanente Medical Care Program. Tissue samples were available for 1,953 individuals, of which 1,894 had carcinoma tissue and 1,599 had normal mucosa available for statistical analysis. Agilent Human miRNA Microarray V.19.0 was used to generate miRNA expression profiles; validation of expression levels was carried out using quantitative PCR. We used random forest analysis and verified findings …

Approximating Optimal Release In A Deterministic Model For The Sterile Insect Technique, Sergio Ramirez, Luis F. Gordillo

Mathematics and Statistics Faculty Publications

Cost/benefit analyses are essential to support management planning and decisions before launching any pest control program. In particular, applications of the sterile insect technique (SIT) are often prevented by the projected economic burden associated with rearing processes. This has had a deep impact on the technique development and its use on insects with long larval periods, as often seen in beetles. Under the assumptions of long adult timespan and multiple mating, we show how to find approximate optimal sterile release policies that minimize costs. The theoretical framework proposed considers the release of insects by pulses and finds approximate optimal release …

Sexual Assault And The Doctrine Of Chances In The Courtroom, Ryan Wallentine

Research on Capitol Hill

Sexual assault can have devastating and long-lasting effects on victims, but many assailants get away with their crime without being prosecuted.

The doctrine of chances is a rule of evidence allowing evidences of past crimes, wrongs, or acts to show it is unlikely a defendant would be repeatedly and innocently involved in similar, suspicious circumstances.

Given that about 63.3% of assailants are repeat offenders, the doctrine of chances could effectively be used in sexual assault cases.

The main objective is to determine a precise probabilistic threshold for allowing the use of the doctrine of chances in sexual assault cases such …

An Introduction To Differential Geometry Through Computation, Mark E. Fels

Mathematics and Statistics Faculty Presentations

No abstract provided.

Population Density, Not Host Competence, Drives Patterns Of Disease In An Invaded Community, C. L. Searle

Mathematics and Statistics Faculty Presentations

Generalist parasites can strongly influence interactions between native and invasive species. Host competence can be used to predict how an invasive species will affect community disease dynamics; the addition of a highly competent, invasive host is predicted to increase disease. However, densities of invasive and native species can also influence the impacts of invasive species on community disease dynamics. We examined whether information on host competence alone could be used to accurately predict the effects of an invasive host on disease in native hosts. We first characterized the relative competence of an invasive species and a native host species to …

The Kretschmann Scalar, Charles G. Torre

How to... in 10 minutes or less

On a pseudo-Riemannian manifold with metric g, the "Kretschmann scalar" is a quadratic scalar invariant of the Riemann R tensor of g, defined by contracting all indices with g. In this worksheet we show how to calculate the Kretschmann scalar from a metric.