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Molecular Network Control Through Boolean Canalization, David Murrugarra, Elena S. Dimitrova
Molecular Network Control Through Boolean Canalization, David Murrugarra, Elena S. Dimitrova
Mathematics Faculty Publications
Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network modeling where each layer of canalization adds a degree of stability in the dynamics of the network. Recently, dynamic network control approaches have been used for the design of new therapeutic interventions and for other applications such as stem cell reprogramming. This work studies the role of canalization in the control of Boolean molecular networks. It provides a method for identifying the potential edges …