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A Patient-Specific Treatment Model For Graves’ Hyperthyroidism, Balamurugan Pandiyan, Stephen J. Merrill, Flavia Di Bari, Alessandro Antonelli, Salvatore Benvenga
A Patient-Specific Treatment Model For Graves’ Hyperthyroidism, Balamurugan Pandiyan, Stephen J. Merrill, Flavia Di Bari, Alessandro Antonelli, Salvatore Benvenga
Mathematics, Statistics and Computer Science Faculty Research and Publications
Background: Graves’ is disease an autoimmune disorder of the thyroid gland caused by circulating anti-thyroid receptor antibodies (TRAb) in the serum. TRAb mimics the action of thyroid stimulating hormone (TSH) and stimulates the thyroid hormone receptor (TSHR), which results in hyperthyroidism (overactive thyroid gland) and goiter. Methimazole (MMI) is used for hyperthyroidism treatment for patients with Graves’ disease.
Methods: We have developed a model using a system of ordinary differential equations for hyperthyroidism treatment with MMI. The model has four state variables, namely concentration of MMI (in mg/L), concentration of free thyroxine - FT4 (in pg/mL), and concentration of TRAb …