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Full-Text Articles in Physical Sciences and Mathematics
Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin
Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin
Epidemiology and Environmental Health Faculty Publications
Background: African Americans (AAs) suffer a higher stroke burden due to hypertension. Identifying genetic contributors to stroke among AAs with hypertension is critical to understanding the genetic basis of the disease, as well as detecting at-risk individuals.
Methods: In a population comprising over 10,700 AAs treated for hypertension from the Genetics of Hypertension Associated Treatments (GenHAT) and Reasons for Geographic and Racial Differences in Stroke (REGARDS) studies, we performed an inverse variance-weighted meta-analysis of incident stroke. Additionally, we tested the predictive accuracy of a polygenic risk score (PRS) derived from a European ancestral population in both GenHAT and REGARDS AAs …
Machine Learning Analysis Of Single Nucleotide Polymorphism (Snp) Data To Predict Bone Mineral Density In African American Women, Erick Githua Wakayu
Machine Learning Analysis Of Single Nucleotide Polymorphism (Snp) Data To Predict Bone Mineral Density In African American Women, Erick Githua Wakayu
UNLV Theses, Dissertations, Professional Papers, and Capstones
Osteoporosis is a debilitating disease in which an individual’s bones weaken, making bones fragile and more susceptible to fracture. While commonly found amongst postmenopausal Caucasian and Asian women based on previous studies, those of African descent (African American/Black) have largely been ignored when it comes to osteoporotic studies, especially when it comes to Genome Wide Association Studies (GWAS). From GWA studies, we gain access to single nucleotide poly-morphisms (SNPs) that may contribute to certain illnesses, such as osteoporosis. With low Bone Mineral Density (BMD) being one of the primary markers of potential osteoporosis, it is prudent that proper research is …
Whole-Exome Sequencing And Hipsc Cardiomyocyte Models Identify Myrip, Trappc11, And Slc27a6 Of Potential Importance To Left Ventricular Hypertrophy In An African Ancestry Population, Marguerite R. Irvin, Praful Aggarwal, Steven A. Claas, Lisa De Las Fuentes, Anh N. Do, C. Charles Gu, Andrea Matter, Benjamin S. Olson, Amit Patki, Karen Schwander, Joshua D. Smith, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amy J. Turner, Deborah A. Nickerson, Dabeeru C. Rao, Ulrich Broeckel, Donna K. Arnett
Whole-Exome Sequencing And Hipsc Cardiomyocyte Models Identify Myrip, Trappc11, And Slc27a6 Of Potential Importance To Left Ventricular Hypertrophy In An African Ancestry Population, Marguerite R. Irvin, Praful Aggarwal, Steven A. Claas, Lisa De Las Fuentes, Anh N. Do, C. Charles Gu, Andrea Matter, Benjamin S. Olson, Amit Patki, Karen Schwander, Joshua D. Smith, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amy J. Turner, Deborah A. Nickerson, Dabeeru C. Rao, Ulrich Broeckel, Donna K. Arnett
Epidemiology and Environmental Health Faculty Publications
Background: Indices of left ventricular (LV) structure and geometry represent useful intermediate phenotypes related to LV hypertrophy (LVH), a predictor of cardiovascular (CV) disease (CVD) outcomes.
Methods and Results: We conducted an exome-wide association study of LV mass (LVM) adjusted to height2.7, LV internal diastolic dimension (LVIDD), and relative wall thickness (RWT) among 1,364 participants of African ancestry (AAs) in the Hypertension Genetic Epidemiology Network (HyperGEN). Both single-variant and gene-based sequence kernel association tests were performed to examine whether common and rare coding variants contribute to variation in echocardiographic traits in AAs. We then used a data-driven …
Knowledge Of Clinical Measures And Healthcare Adherence In Young Gay And Bisexual Men Living With Hiv/Aids, Harry A. Persaud, Douglas Bruce
Knowledge Of Clinical Measures And Healthcare Adherence In Young Gay And Bisexual Men Living With Hiv/Aids, Harry A. Persaud, Douglas Bruce
DePaul Discoveries
Knowledge of HIV/AIDS test results and adherence to healthcare interventions are two important outcomes that reflect proper HIV/AIDS management. This study aimed to determine which demographic and HIV acceptance measures were significantly associated with health literacy and adherence indicators in young MSM. 200 HIV/AIDS positive young MSM completed computer based surveys regarding demographics, HIV/AIDS health literacy indicators, and HIV/AIDS acceptance measures. It was found that young African American MSM, in comparison to young white MSM, had lower odds of knowing both viral load and CD4 measures; health literacy indicators. Further, participants who had a high school diploma were found to …