Physical Sciences and Mathematics Commons^™

Joint Small-Angle X-Ray And Neutron Scattering Data Analysis Of Asymmetric Lipid Vesicles, Barbara Eicher, Frederick A. Heberle, Drew Marquardt, Gerald N. Rechberger, John Katsaras, Georg Pabst

Chemistry and Biochemistry Publications

Low- and high-resolution models describing the internal transbilayer structure of asymmetric lipid vesicles have been developed. These models can be used for the joint analysis of small-angle neutron and X-ray scattering data. The models describe the underlying scattering length density/electron density profiles either in terms of slabs or through the so-called scattering density profile, previously applied to symmetric lipid vesicles. Both models yield structural details of asymmetric membranes, such as the individual area per lipid, and the hydrocarbon thickness of the inner and outer bilayer leaflets. The scattering density profile model, however, comes at a cost of increased computational effort …