Physical Sciences and Mathematics Commons^™

Towards The Identification Of Protein Complexes And Functional Modules By Integrating Ppi Network And Gene Expression Data, Min Li, Xuehong Wu, Jianxin Wang, Yi Pan

Computer Science Faculty Publications

Background: Identification of protein complexes and functional modules from protein-protein interaction (PPI) networks is crucial to understanding the principles of cellular organization and predicting protein functions. In the past few years, many computational methods have been proposed. However, most of them considered the PPI networks as static graphs and overlooked the dynamics inherent within these networks. Moreover, few of them can distinguish between protein complexes and functional modules.

Results: In this paper, a new framework is proposed to distinguish between protein complexes and functional modules by integrating gene expression data into protein-protein interaction (PPI) data. A series of time-sequenced subnetworks …