Physical Sciences and Mathematics Commons^™

A New Essential Protein Discovery Method Based On The Integration Of Protein-Protein Interaction And Gene Expression Data, Min Li, Hanhui Zhang, Jian-Xin Wang, Yi Pan

Computer Science Faculty Publications

The article offers information on a study conducted on the essential protein discovery method, PeC, which is based on the integration of protein-protein interaction and gene expression data. It states that PeC was developed on the basis of the definitions of edge clustering coefficient (ECC) and Pearson's correlation coefficient (PCC). It mentions that a list of essential proteins of Saccharomyces cerevisiae were collected.

Background: Identification of essential proteins is always a challenging task since it requires experimental approaches that are time-consuming and laborious. With the advances in high throughput technologies, a large number of protein-protein interactions are available, which have …