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Full-Text Articles in Physical Sciences and Mathematics
Protection Against Experimental Autoimmune Myocarditis Is Mediated By Interleukin-10-Producing T Cells That Are Controlled By Dendritic Cells, Ya Li, Janet S. Heuser, Stanley D. Kosanke, Mark E. Hemric, Madeleine W. Cunningham
Protection Against Experimental Autoimmune Myocarditis Is Mediated By Interleukin-10-Producing T Cells That Are Controlled By Dendritic Cells, Ya Li, Janet S. Heuser, Stanley D. Kosanke, Mark E. Hemric, Madeleine W. Cunningham
Faculty Publications and Presentations
Experimental autoimmune myocarditis (EAM) can be induced in the Lewis rat by cardiac myosin or its cryptic S2-16 peptide epitope (amino acids1052 to 1076). To investigate cellular mechanisms and the role of antigen-presenting cells in regulation of myocarditis, we induced protection against EAM in Lewis rats by administration of S2-16 peptide in incomplete Freund’s adjuvant (IFA). Protection to EAM was associated with activation of S2-16-reactive splenocytes secreting high levels of interleukin (IL)-10 and reduced levels of interferon- and IL-2. Adoptive transfer of S2-16:IFA-induced splenocytes producing IL-10 suppressed myocarditis induction in syngeneic recipients, suggesting their regulatory cell nature. However, exposure of …
Who Believes What? Clearing Up Confusion Over Intelligent Design And Young-Earth Creationism, Marcus R. Ross
Who Believes What? Clearing Up Confusion Over Intelligent Design And Young-Earth Creationism, Marcus R. Ross
Marcus R. Ross
The question of what differentiates young-Earth creationism (YEC) from Intelligent Design (ID) has resulted in inaccurate and confusing terminology, and hinders both understanding and dialogue. Though both YEC and ID groups have drawn distinctions between themselves, previous attempts to classify design-based positions on origins have been unable to adequately resolve their relationships. The Nested Hierarchy of Design, a multiple-character classification system, categorizes teleological positions according to the strength of claims regarding the reality, detectability, source, method, and timing of design, and results in an accurate and robust classification of numerous positions. This method avoids the philosophical and theological pitfalls of …