Antibacterial Activity, Structure-Activity Relationships, And Scale-Up Reaction Of 1,3,4-Oxadiazoles, Olivia Marie Smith

Undergraduate Honors Thesis Projects

Oxadiazoles are compounds in the field of organic chemistry that have been gathering interest in the medicinal chemistry and microbiology communities for their biological properties, which range from anti-inflammatory agents, to chemotherapy drugs, to antibiotics. The synthesis of oxadiazoles can be difficult due to the expensive and complex nature of the techniques used as well as the volatile reagents and elevated temperatures that are often required in organic synthesis. The Grote lab has recently developed a new method for the synthesis of 1,3,4-oxadiazoles under mild conditions. The goals of this thesis were thus twofold: to develop a viable scale-up procedure …

Presence Of Glyphosate In First Order Streams Associated With Rainfall Events, Julie Platz

Undergraduate Honors Thesis Projects

Glyphosate is widely used in the United States and has recently been described as both mobile and persistent in soils and bodies of water. There is little research however, on the variability of glyphosate concentration in runoff based on different land use types. For this study an evaluation of samples from different land uses are used to assess glyphosate concentrations in first order streams during a runoff event. The intent was to compare three sites with a. known commercial applications, b. known lack of applications (organic), and c. assumed limited application of glyphosate. There was no significant difference in glyphosate …

Investigating The Synthesis Of 1,3,4-Oxadiazoles Via A Novel Two-Step-One-Pot Cyclodehydration Reaction, Brittney Sowers

Undergraduate Honors Thesis Projects

The given research will investigate synthetic strategies and differential functionalization of 1,3,4- oxadiazoles in hopes of obtaining moderate to high yields. Particularly, the effects of electron withdrawing on oxadiazoles will reveal more information about possible mechanistic details and reaction optimization.

The research in this report is a part of a lager research effort being investigated by Dr. Robin Grote. This research is ongoing and has evolved from its start in the Grote Lab. Previously, the Grote Lab has focused on the formation of a patented heterocycle that contained an amino-pyrazine functional group. Currently, our research has shifted focus to the …

Recovery Potential Of The Mussel Communities In The Lower Section Of Big Walnut Creek, Jared B. Ellenbogen

Undergraduate Honors Thesis Projects

Since the enactment of the 1977 Clean Water Act, biologists have created numerous multimetric assessment tools to evaluate the biological integrity of water resources, using biological criteria. The integrity of Big Walnut Creek, Ohio, has been in flux since the 1955 construction of Hoover Dam, and while current water quality is high, mussel communities in the creek have yet to recover to historical levels. This study sought to determine the cause of the decline in the mussels in the lower section of the creek below the dam. Historical creek data, including a fish-based index of biotic integrity (f-IBI), invertebrate community …