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On The Protective Properties Of Glycine Based Osmolytes In A Thiol Reducing Environment, John Michael Hausman
On The Protective Properties Of Glycine Based Osmolytes In A Thiol Reducing Environment, John Michael Hausman
Dissertations, Master's Theses and Master's Reports - Open
The protective properties of osmolytes have been studied intently for decades. Originally used to aid in the crystallization of proteins in x-ray diffraction studies, these cosolvents have been shown to reverse protein denaturation and aggregation. Osmolytes aid extremophiles in surviving harsh environments by preferentially excluding themselves from the surface of the protein, thus directing water molecules to the protein’s surface. These osmolytes are naturally found in many health foods and also in many daily use products such as shampoo. Due to their osmoprotective effect their use in everyday consumer product is increasing. Consumers also supplement their diets with thiol-based antioxidants …