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Full-Text Articles in Physical Sciences and Mathematics
Evidence Of Direct Interaction Between Cisplatin And The Caspase-Cleaved Prostate Apoptosis Response-4 Tumor Suppressor, Krishna K. Raut, Samjhana Pandey, Gyanendra Kharel, Steven M. Pascal
Evidence Of Direct Interaction Between Cisplatin And The Caspase-Cleaved Prostate Apoptosis Response-4 Tumor Suppressor, Krishna K. Raut, Samjhana Pandey, Gyanendra Kharel, Steven M. Pascal
Chemistry & Biochemistry Faculty Publications
Prostate apoptosis response-4 (Par-4) tumor suppressor protein has gained attention as a potential therapeutic target owing to its unique ability to selectively induce apoptosis in cancer cells, sensitize them to chemotherapy and radiotherapy, and mitigate drug resistance. It has recently been reported that Par-4 interacts synergistically with cisplatin, a widely used anticancer drug. However, the mechanistic details underlying this relationship remain elusive. In this investigation, we employed an array of biophysical techniques, including circular dichroism spectroscopy, dynamic light scattering, and UV–vis absorption spectroscopy, to characterize the interaction between the active caspase-cleaved Par-4 (cl-Par-4) fragment and cisplatin. Additionally, elemental analysis was …
Peptide Inhibitor Of Complement C1 (Pic1) Rapidly Inhibits Complement Activation After Intravascular Injection In Rats, Julia A. Sharp, Pamela S. Hair, Haree K. Pallera, Parvathi S. Kumar, Clifford T. Mauriello, Julius O. Nyalwidhe, Cody A. Phelps, Dalnam Park, Nicole M. Thielens, Stephen M. Pascal, Waldon Chen, Diane M. Duffy, Frank A. Lattanzio, Kenji M. Cunnion, Neel K. Krishna
Peptide Inhibitor Of Complement C1 (Pic1) Rapidly Inhibits Complement Activation After Intravascular Injection In Rats, Julia A. Sharp, Pamela S. Hair, Haree K. Pallera, Parvathi S. Kumar, Clifford T. Mauriello, Julius O. Nyalwidhe, Cody A. Phelps, Dalnam Park, Nicole M. Thielens, Stephen M. Pascal, Waldon Chen, Diane M. Duffy, Frank A. Lattanzio, Kenji M. Cunnion, Neel K. Krishna
Chemistry & Biochemistry Faculty Publications
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases. Consequently, therapeutic modulators of the classical, lectin and alternative pathways of the complement system are currently in preclinical and clinical development. Our laboratory has identified a peptide that specifically inhibits the classical and lectin pathways of complement and is referred to as Peptide Inhibitor of Complement C1 (PIC1). In this study, we determined that the lead PIC1 variant demonstrates a salt-dependent binding to C1q, the initiator molecule of the classical pathway. Additionally, this peptide bound to the lectin pathway initiator …