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Full-Text Articles in Physical Sciences and Mathematics
A Comprehensive Uncertainty Analysis And Method Of Geometric Calibration For A Circular Scanning Airborne Lidar, Michael Oliver Gonsalves
A Comprehensive Uncertainty Analysis And Method Of Geometric Calibration For A Circular Scanning Airborne Lidar, Michael Oliver Gonsalves
Dissertations
This dissertation describes an automated technique for ascertaining the values of the geometric calibration parameters of an airborne lidar. A least squares approach is employed that adjusts the point cloud to a single planar surface which could be either a narrow airport runway or a dynamic sea surface. Going beyond the customary three boresight angles, the proposed adjustment can determine up to eleven calibration parameters to a precision that renders a negligible contribution to the point cloud’s positional uncertainty.
Presently under development is the Coastal Zone Mapping and Imaging Lidar (CZMIL), which, unlike most contemporary systems that use oscillating mirrors …
Folate Receptor-Targeted Delivery Of Small Interfering Rna To Cancer Cells, Yilin Zhang
Folate Receptor-Targeted Delivery Of Small Interfering Rna To Cancer Cells, Yilin Zhang
Dissertations
The vitamin folic acid (folate, FA) has been extensively explored as a targeting ligand to deliver a variety of diagnostic/prognostic/therapeutic agents into various tumors through the assistance of its receptor – the folate receptor (FR). FR is over-expressed in many types of human cancer and can mediate internalization of FA-conjugates through an endocytic pathway. The discovery of small interfering RNA (siRNA), which is cable of inducing potent gene silencing in a sequence-specific manner, provides an excellent molecular tool to suppress aberrant gene expression in malignancies, and therefore siRNA has the potential to revolutionize cancer therapeutics. Towards the goal of developing …