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- ADSCs (1)
- Breast Cancer (1)
- Cytokines (1)
- Data Information Knowledge Wisdom (1)
- Data integrity (1)
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- Dorsiflexion (1)
- Double-edged sword (1)
- Exosomes (1)
- GAA (1)
- Integration (1)
- Knowledge (1)
- Lateral ankle sprain (1)
- MTDS (1)
- MWM (1)
- MiRNA (1)
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- Mitochondria (1)
- Mitochondria dysfunction (1)
- Mitochondrial diseases (1)
- MtDNA (1)
- Oncological safety (1)
- Oxidative Phosphorylation (1)
- Pharmaceutical knowledge ecosystem (1)
- Plantarfascia (1)
- Proliferation (1)
- Quality risk management (1)
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Articles 1 - 6 of 6
Full-Text Articles in Physical Sciences and Mathematics
Editorial - Sure Journal Vol 4, Anne M. Friel
Editorial - Sure Journal Vol 4, Anne M. Friel
SURE Journal: Science Undergraduate Research Experience Journal
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The Interaction Of Adipose Derived Stem Cells And Breast Cancer, Natasha Cunningham, Ava O'Meara, Cathy L. Brougham
The Interaction Of Adipose Derived Stem Cells And Breast Cancer, Natasha Cunningham, Ava O'Meara, Cathy L. Brougham
SURE Journal: Science Undergraduate Research Experience Journal
Introduction: Mesenchymal stem cells are adult stem cells capable of self-renewal and multilineage differentiation (Schweizer et al., 2015). Adipose derived stem cells have been used in breast reconstruction following surgical intervention in breast cancer patients. MicroRNAs have been linked to gene regulation essential in oncogenic, and tumour suppression as well as cell signalling pathways in BC.
Aim: To research the hypothesis of ADSCs and their therapeutic properties in BC patients.
Methods: Proliferation assays were carried out to demonstrate how ADSC conditioned media influenced BC cell lines MDA-MB-231, SKBR3, and T47D. The expression of six miRNAs (miR-21, miR-133, miR-222, miR-146, miR-221, …
The Acute Effects Of Talocrural Mwm Compared With The Application Of Soft-Tissue Of The Plantarfascia On Chronic Lateral Ankle Sprains For Ankle Dorsiflexion R.O.M., Peter Hempenstall, Brian O'Rourke
The Acute Effects Of Talocrural Mwm Compared With The Application Of Soft-Tissue Of The Plantarfascia On Chronic Lateral Ankle Sprains For Ankle Dorsiflexion R.O.M., Peter Hempenstall, Brian O'Rourke
SURE Journal: Science Undergraduate Research Experience Journal
Previous research has looked at various treatment remedies for improving acute ankle Dorsiflexion Range of Motion (DFROM) post chronic Lateral Ankle Sprain (LAS). Mulligan’s Mobilisation with Movement (MWM) appears frequently however, the significance and mechanism remain quite conflicting (Gilbreath et al., 2015). It is also known that after a LAS, the Lateral Ligament Complex (LLC) is compromised and the calcaneus inverts, increasing stiffness of plantarfascia (Al-Mohrej & Al-Kenani, 2016, Denegar et al., 2002, Loudon & Bell, 1996). The objective of this study was to further explore the effectiveness of MWM compared with soft-tissue (ST) application of the plantarfascia on acute …
Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill
Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill
SURE Journal: Science Undergraduate Research Experience Journal
Mitochondria are cytoplasmic, double-membrane organelles that synthesise adenosine triphosphate (ATP). Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. These complexes form a chain that allows the passage of electrons down the electron transport chain (ETC) through a proton motive force, creating ATP from adenosine diphosphate (ADP). This study aims to explore current and prospective therapies for mitochondrial disorders (MTDS). MTDS are clinical syndromes coupled with abnormalities …
Exploring Pathways From Data To Knowledge To Insights In The Pharmaceutical Industry: ‘Introducing The Pharmaceutical Knowledge Ecosystem’, Melanie J. Adams, Paige E. Kane, Anne Greene (Editor), Martin Lipa
Exploring Pathways From Data To Knowledge To Insights In The Pharmaceutical Industry: ‘Introducing The Pharmaceutical Knowledge Ecosystem’, Melanie J. Adams, Paige E. Kane, Anne Greene (Editor), Martin Lipa
Level 3
The ecosystem of how the pharmaceutical industry acquires data, transforms these data into tangible knowledge, and derives valuable insights throughout the process, is highly complex. Data, information, knowledge, and the resulting insights, are necessary to support decision- making, manage risk, problem solve, ensure product realisation, enable continual improvement, and enhance operational effectiveness. Building on the fundamental concepts established in the well-known Data Information Knowledge Wisdom (DIKW) hierarchy, this paper reviews the basic concepts involved in the DIKW pathway and begins to relate these concepts to both established capabilities (e.g., PAT), existing requirements (e.g., data integrity), and emerging trends in the …
Improving Risk-Based Decision Making (Rbdm) Effectiveness Through A Framework Which Integrates Knowledge And Risk, Martin Lipa, Valerie Mulholland, Anne Greene (Editor)
Improving Risk-Based Decision Making (Rbdm) Effectiveness Through A Framework Which Integrates Knowledge And Risk, Martin Lipa, Valerie Mulholland, Anne Greene (Editor)
Level 3
This paper explores the emergence of the importance of knowledge in Risk-Based Decision Making (RBDM) and Quality Risk Management (QRM) through a detailed review of ICH Q9(R1) (Step 2) and presents a framework(the RKI cycle) to integrate knowledge and risk and associated six principles to operationalise it.