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Full-Text Articles in Physical Sciences and Mathematics
The Coastal Monitor: Vol. 10 No. 2, John Tanacredi Ph.D.
The Coastal Monitor: Vol. 10 No. 2, John Tanacredi Ph.D.
The Coastal Monitor
Stephen J. Gould’s prophetic piece, “The Golden Rule: A Proper Scale for Our Environmental Crisis”, noted that, “Patience enjoys a long pedigree of favor”, which he elaborated, “usually involves a deep understanding of the fundamental principle… rarely grasped in daily life – the effects of scale.” Scientists observe changes incessantly, in dimensions and time, from microscopic conditions of cellular biology to the inconceivable distances of galaxies and their influences on Earth.
The Coastal Monitor: Vol. 10 No. 1, John Tanacredi Ph.D.
The Coastal Monitor: Vol. 10 No. 1, John Tanacredi Ph.D.
The Coastal Monitor
New Year’s Day has always been, for me, a time to reflect and project into the near future. Nature’s influence on us all certainly tops my listing with several environmental concerns. For example, the frequency and intensity of hurricanes to Long Island. A decade has passed since Superstorm Sandy re-opened the “Old Inlet” on Long Island which now has mostly naturally closed. So, the new year immediately prompts me to assess the previous year’s Hurricane Ian, a Category 4 system, with winds exceeding 150 mph, which had considerable impact in Florida, and then proceeded north resulting in over 2 inches …
Diverse Secondary Metabolites Are Expressed In Particle-Associated And Free-Living Microorganisms Of The Permanently Anoxic Cariaco Basin, David Gellar-Mcgrath, Paraskevi Mara, Gordon T. Taylor, Elizabeth A. Suter, Virginia Edgcomb, Maria Pachiadaki
Diverse Secondary Metabolites Are Expressed In Particle-Associated And Free-Living Microorganisms Of The Permanently Anoxic Cariaco Basin, David Gellar-Mcgrath, Paraskevi Mara, Gordon T. Taylor, Elizabeth A. Suter, Virginia Edgcomb, Maria Pachiadaki
Faculty Works: Biology, Chemistry, and Environmental Studies
Secondary metabolites play essential roles in ecological interactions and nutrient acquisition, and are of interest for their potential uses in medicine and biotechnology. Genome mining for biosynthetic gene clusters (BGCs) can be used for the discovery of new compounds. Here, we use metagenomics and metatranscriptomics to analyze BGCs in free-living and particle-associated microbial communities through the stratified water column of the Cariaco Basin, Venezuela. We recovered 565 bacterial and archaeal metagenome-assembled genomes (MAGs) and identified 1154 diverse BGCs. We show that differences in water redox potential and microbial lifestyle (particle-associated vs. free-living) are associated with variations in the predicted composition …
The Kappa Opioid Receptor: Candidate Pharmacotherapeutic Target For Multiple Sclerosis, Brian Reed, Surya Dutta
The Kappa Opioid Receptor: Candidate Pharmacotherapeutic Target For Multiple Sclerosis, Brian Reed, Surya Dutta
Faculty Works: Biology, Chemistry, and Environmental Studies
Multiple sclerosis (MS) afflicts millions of people worldwide. While multiple therapeutics have recently been developed and approved as treatment agents, they are not 100% effective. Recent developments investigating the endogenous opioid system involvement in MS has revealed that agonists of the kappa opioid receptor (KOR) have beneficial effects in both animal models of MS (and demyelinating disorders more generally) as well as in vitro models of remyelination. Several groups have contributed to this development. We summarize here the findings of these published studies, with comparisons of the effects and discussion of similarities and differences. The effects of KOR agonists involve …