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Full-Text Articles in Physical Sciences and Mathematics
The Temperature-Dependent Conformational Ensemble Of Sars-Cov-2 Main Protease (Mpro), Ali Ebrahim, Blake T. Riley, Desigan Kumaran, Babak Andi, Martin R. Fuchs, Sean Mcsweeney, Daniel A. Keedy
The Temperature-Dependent Conformational Ensemble Of Sars-Cov-2 Main Protease (Mpro), Ali Ebrahim, Blake T. Riley, Desigan Kumaran, Babak Andi, Martin R. Fuchs, Sean Mcsweeney, Daniel A. Keedy
Publications and Research
The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or Mpro, is a promising target for development of novel antiviral therapeutics. Previous X-ray crystal structures of Mpro were obtained at cryogenic temperature or room temperature only. Here we report a series of high-resolution crystal structures of unliganded Mpro across multiple temperatures from cryogenic to physiological, and another at high humidity. We interrogate these datasets with parsimonious multiconformer models, multi-copy ensemble models, and isomorphous difference density maps. Our analysis reveals a temperature-dependent conformational landscape for Mpro, including …
Archipelago On Lockdown: An Assessment Of The Effects Of The Covid-19 Pandemic On Philippines’ Micro, Small, And Medium Enterprises (Msmes) Across The Food Value Chain, Remund Jordan D. Labios, Dinah Pura T. Depositario, Nohreen Ethel P. Manipol, Renen Szillardo C. De Guzman, Dia Noelle F. Velasco
Archipelago On Lockdown: An Assessment Of The Effects Of The Covid-19 Pandemic On Philippines’ Micro, Small, And Medium Enterprises (Msmes) Across The Food Value Chain, Remund Jordan D. Labios, Dinah Pura T. Depositario, Nohreen Ethel P. Manipol, Renen Szillardo C. De Guzman, Dia Noelle F. Velasco
Journal of Economics, Management and Agricultural Development
The paper examined the effects of COVID-19 pandemic on the Philippines’ MSMEs across the food value chain and the strategies that food-based MSMEs employed to cope with disruptions. A food value chain framework was used to
analyze the food-based MSMEs, focusing on the input and service provision, production/farming, processing, transport and storage, retailing, and consumption. Results revealed the following: (1) different quarantine protocols across provincial and local boundaries contributed to the complexity of transporting inputs and products; (2) limited mobility of manpower contributed to the challenges of continuing business operations; (3) there was an observed increase in new financing programs …