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Full-Text Articles in Physical Sciences and Mathematics
Targeting C-Reactive Protein For The Treatment Of Cardiovascular Disease, Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson, Stephen P. Wood
Targeting C-Reactive Protein For The Treatment Of Cardiovascular Disease, Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson, Stephen P. Wood
J. A. Aquilina
Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect long-term prognosis. There is thus an important unmet medical need for new cardioprotective and neuroprotective treatments. We have previously shown that human C-reactive protein (CRP), the classical acute-phase protein that binds to ligands exposed in damaged tissue and then activates complement1, increases myocardial and cerebral infarct size in rats subjected to coronary or cerebral artery ligation, respectively2,3. …
An Automated Land Subdivision Tool For Urban And Regional Planning: Concepts, Implementation And Testing, Rohan Wickramasuriya, Laurie A. Chisholm, Marjetta Puotinen, Nicholas Gill, Peter Klepeis
An Automated Land Subdivision Tool For Urban And Regional Planning: Concepts, Implementation And Testing, Rohan Wickramasuriya, Laurie A. Chisholm, Marjetta Puotinen, Nicholas Gill, Peter Klepeis
Nicholas J Gill
Simulation of the land subdivision process is useful in many applied and research areas. Planners use such tools to understand potential impacts of planning regulations prior to their implementation. While the credibility of both land-use change and urban growth models would be enhanced by integrating capabilities to simulate land subdivision, such research is lacking in the published literature. Of the few subdivision tools that exist, most are either not fully-automated or are unable to generate realistic subdivision layouts. This limits their applicability, particularly for high resolution land-use change models. In this paper, we present a fully-automated land subdivision tool that …