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Full-Text Articles in Physical Sciences and Mathematics
Probing Proteasome Inhibition By Metal Copmplexes As A New Route For Anticancer Therapy, Dajena Tomco
Probing Proteasome Inhibition By Metal Copmplexes As A New Route For Anticancer Therapy, Dajena Tomco
Wayne State University Dissertations
The scope of this thesis is focused towards the development of metal-containing coordination compounds as potential therapeutic agents. Efforts of this research involve the design, synthesis, and purification of these complexes, as well as their evaluation by spectroscopic, spectrometric, and electrochemical characterization. The antineoplastic properties of these metal-containing pro-drugs are tested against the inhibition activity of the 26S proteasome. Selected metal ions ranging from transition to main group elements have been incorporated in various ligand systems containing phenolate and pyridyl donor sets. The mechanistic behavior of these complexes in solution has been thoroughly investigated along with their in vitro anticancer …
Modulation Of Water-Exchange Rates Of Lanthanide(Iii)-Containing Complexes Using Polyethylene Glycol, Buddhima Nirodhi Siriwardena-Mahanama
Modulation Of Water-Exchange Rates Of Lanthanide(Iii)-Containing Complexes Using Polyethylene Glycol, Buddhima Nirodhi Siriwardena-Mahanama
Wayne State University Dissertations
MODULATION OF WATER-EXCHANGE RATES OF LANTHANIDE(III)-CONTAINING COMPLEXES USING POLYETHYLENE GLYCOL
by
BUDDHIMA N. SIRIWARDENA-MAHANAMA
May 2014
Advisor: Dr. Matthew J. Allen
Major: Chemistry
Degree: Doctor of Philosophy
A modular system of lanthanide(III)-containing polyethylene glycol (PEG) conjugates was synthesized and characterized to investigate the influence of length and density of PEG on water-exchange rates of lanthanide(III)-containing complexes. The water-exchange rates of lanthanide(III)-containing complexes contribute to the efficiency of these complexes as T1-shortening and paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents for magnetic resonance imaging (MRI). Because the mechanism of these two MRI methods is vastly different, there is …
Redox-Active Trivalent Metallosurfactants With Low Global Symmetry For Molecule-Based Electronics: Spectroscopic, Electrochemical, And Amphiphilic Properties Of New Molecular Materials For Current-Voltage Measurements In M|Lb-Monolayer|M Devices, Lanka Dilruksi Wickramasinghe Wickramasinghe Arachchilage
Redox-Active Trivalent Metallosurfactants With Low Global Symmetry For Molecule-Based Electronics: Spectroscopic, Electrochemical, And Amphiphilic Properties Of New Molecular Materials For Current-Voltage Measurements In M|Lb-Monolayer|M Devices, Lanka Dilruksi Wickramasinghe Wickramasinghe Arachchilage
Wayne State University Dissertations
LANKA D. W. WICKRAMASINGHE ARACHCHILAGE
August 2014
Advisor: Professor Cláudio N. Verani
Major: Chemistry (Inorganic)
Degree: Doctor of Philosophy
The silicon-based microelectronic industry has made remarkable technological advancements. Among these, new generation consumer electronics, telecommunication devices, and high performance data processing smart devices are of special interest. At present, electronic components existing on a single silicon chip grow rapidly, and soon the miniaturization process of electrical components will face limitations due to heat dissipation. Therefore, as an advanced alternative for silicon-based electronic components, the investigation of nanoscale molecular electronic devices is of great importance. This dissertation research is focused on …