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Design, Synthesis And Analysis Of Potential Photo-Activatable Cathepsin K Inhibitors, Khalin Evania Nisbett
Design, Synthesis And Analysis Of Potential Photo-Activatable Cathepsin K Inhibitors, Khalin Evania Nisbett
Wayne State University Theses
Abstract
DESIGN, SYNTHESIS AND ANALYSIS OF POTENTIAL PHOTO-ACTIVATABLE CATHEPSIN K INHIBITORS
by
KHALIN NISBETT
May 2017
Advisor: Dr. Jeremy Kodanko
Major: Chemistry
Degree: Master of Science
Tightly regulated cysteine CA proteases play a major role in maintaining the homeostasis within cells. Subsequently, when these proteases are dysregulated and mislocalized they disrupt healthy cell dynamics and contribute to many life-threatening pathologies such arteriosclerosis, osteoporosis and cancer. As such many pharmaceutical companies and research teams are highly interested in these proteases as targets. One emergent strategy is the spatiotemporal control of biological processes. In relation to this, a series of spatiotemporally controlled …
Synthesis Of Cryptands For Eu2+-Containing Complexes, Chengcheng Wang
Synthesis Of Cryptands For Eu2+-Containing Complexes, Chengcheng Wang
Wayne State University Theses
Eu2+-containing complexes have considerable applications in synthetic chemistry, medical diagnosis, and materials science. However, Eu2+ is easily oxidized in solution when exposed to air. Allen and coworkers have demonstrated that Eu2+ can be stabilized by functionalized cryptands. Based on this idea, I focused my research on synthesizing cryptands. The progress towards synthesizing several modified cryptands is described in the thesis. The Eu2+-containing complexes of these cryptates have potential applications as magnetic resonance imaging contrast agents, luminescent materials, and magnetic materials.