Physical Sciences and Mathematics Commons^™

Biotransformation Of Doxycycline By Brevundimonas Naejangsanensis And Sphingobacterium Mizutaii Strains, Ting He, Jianguo Bao, Yifei Leng, Daniel D. Snow, Shuqiong Kong, Tong Wang, Xu Li

Nebraska Water Center: Faculty Publications

The fate of doxycycline (DC), a second generation tetracycline antibiotic, in the environment has drawn increasing attention in recent years due to its wide usage. Little is known about the biodegradability of DC in the environment. The objective of this study was to characterize the biotransformation of DC by pure bacterial strains with respect to reaction kinetics under different environmental conditions and biotransformation products. Two bacterial strains, Brevundimonas naejangsanensis DD1 and Sphingobacterium mizutaii DD2, were isolated from chicken litter and characterized for their biotransformation capability of DC. Results show both strains rely on cometabolism to biotransform DC with tryptone as …